ArticleBMC gastroenterology2014
Occurrence of Helicobacter pylori and Epstein-Barr virus infection in endoscopic and gastric cancer patients from Northern Brazil.
Article in BMC gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Gastric cancer burden and regional disparities among Helicobacter pylori-positive patients in the Americas: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Pooled it
- Epstein-Barr Virus and Helicobacter pylori Co-Infection in Gastric Cancer: A Systematic Review and Meta-Analysis of Case-Control and Cross-Sectional Studies.Asian Pacific journal of cancer prevention : APJCP · 2026Pooled it
- Clinicopathological Significance of EBV-Infected Gastric Carcinomas: A Meta-Analysis.Medicina (Kaunas, Lithuania) · 2020Pooled it
- Epstein-Barr Virus and Gastric Cancer Risk: A Meta-analysis With Meta-regression of Case-control Studies.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2016Pooled it
- Article
- Helicobacter pylori CagA+ strains modulate colorectal pathology by regulating intestinal flora.BMC gastroenterology · 2025Article
- Article
- Article
- Detection of Epstein-Barr virus in gastric adenocarcinoma: qPCR and FISH comparison.Medical microbiology and immunology · 2022Article
- Higher viral load of Epstein-Barr virus in gastric cancer compared with non-cancerous gastroduodenal tissues.Le infezioni in medicina · 2022Article
- Quantitative difference of oral pathogen between individuals with gastric cancer and individuals without cancer.Oncotarget · 2021Article
- Article
- Review
- Downregulated genes by silencingAging · 2020Article
- Detection of Epstein-Barr Virus DNA in Gastric Biopsies of Pediatric Patients with Dyspepsia.Pathogens (Basel, Switzerland) · 2020Article
- Epstein-Barr virus infection in patients with chronic gastritis without Helicobacter pylori infection.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Article
- Epstein-Barr Virus andPathogens (Basel, Switzerland) · 2020Review
- Sex difference in incidence of gastric cancer: an international comparative study based on the Global Burden of Disease Study 2017.BMJ open · 2020Article
- Epstein-Barr virus is absent in gastric superficial neoplastic lesions.Virchows Archiv : an international journal of pathology · 2019Article
- Prevalence ofJournal of global oncology · 2019Article
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelicobacter pylori (HP) and Epstein-Barr virus (EBV) have been associated with cancer development. We evaluated the prevalence of HP, HP CagA+ and EBV infection in gastric cancer (GC) samples from adults and in gastric tissues from patients who underwent upper endoscopy (UE).
methodsSamples from UE and GC were collected to investigate the presence of HP infection and the HP virulence factor CagA by a urease test and PCR. The presence of EBV was detected by Eber-1 in situ hybridization.
resultsIn UE, 85.5% of juvenile patients showed some degree of gastritis (45.3% of patients with mild gastritis and 54.7% with moderate/severe gastritis) and patients with mild gastritis were younger than patients with moderate/severe gastritis. Among adults, 48.7% presented mild gastritis and 51.3% moderate/severe gastritis. HP infection was detected in 0% of normal mucosa, 58.5% of juvenile gastritis patients, 69.2% of adult gastritis patients and 88% of GC patients. In these same groups, HP CagA+ was detected in 0%, 37.7%, 61.5% and 67.2% of tissue samples, respectively. In juvenile patients, HP infection was more common in those with gastritis than in normal samples (p = 0.004). The patients with either HP or HP CagA+ were older than patients without these pathogens (p < 0.05). In juvenile patients, HP infection was more frequent in cases of moderate/severe gastritis than in cases of mild gastritis (p = 0.026). Moreover, in patients with GC, HP infection was more frequent in males than in females (p = 0.023). GC patients with HP CagA+ were older than patients with HP CagA- (p = 0.027). HP CagA+ was more common in intestinal-type than diffuse-type GC (p = 0.012). HP CagA+ was also associated with lymph-node (p = 0.024) and distal (p = 0.005) metastasis. No association between EBV infection and HP infection or any clinicopathological variable was detected.
conclusionsOur results suggest that HP is involved in the pathophysiology of severe gastric lesions and in the development of GC, particularly when CagA+ is present. EBV was not the primary pathogenic factor in our samples.
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