Evidence map›Paper›PMID 25318757›Full record

ReviewClinical journal of the American Society of Nephrology : CJASN2014

Thick ascending limb of the loop of Henle.

David B Mount

Open access · bronzeAbstract readReview
In one paragraph

Review in Clinical journal of the American Society of Nephrology : CJASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 182 citations in OpenAlex.

  1. Review
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  10. Endocrine regulation of uromodulin in aging.Frontiers in endocrinology · 2026
    Review
  11. Article
  12. Review
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  20. Flow-dependent transport processes 2024: filtration, absorption, and secretion.American journal of physiology. Renal physiology · 2025
    Article

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

David B MountRenal Division, Brigham and Women's Hospital, Veterans Affairs Boston Healthcare System, Boston, Massachusetts dmount@partners.org.
Brigham and Women's Hospital · US

Funding

The Pathobiology of NephrolithiasisP01DK070756 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI MOUNT, DAVID BRUCE · 2007 to 2011
$8.4M
NIDDK NIH HHS DK070756NIDDK NIH HHS P01 DK070756
6 · The paper itself

Abstract

The thick ascending limb occupies a central anatomic and functional position in human renal physiology, with critical roles in the defense of the extracellular fluid volume, the urinary concentrating mechanism, calcium and magnesium homeostasis, bicarbonate and ammonium homeostasis, and urinary protein composition. The last decade has witnessed tremendous progress in the understanding of the molecular physiology and pathophysiology of this nephron segment. These advances are the subject of this review, with emphasis on particularly recent developments.

Indexed as

Ammonium CompoundsBicarbonatesCalciumChloridesHomeostasisHumansIon TransportLoop of HenleMagnesiumPotassiumSodiumUromodulinAmmonium CompoundsBicarbonatesCalciumChloridesMagnesiumPotassiumSodiumUromodulinacidosiscalcium receptorNa transportrenal physiologywater transport

Identifiers

PMID25318757
PMCPMC4220766
OpenAlexW2110858809

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.