ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015
CRKL protein overexpression enhances cell proliferation and invasion in pancreatic cancer.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Comprehensive DNA methylation profiling by MeDIP-NGS identifies potential genes and pathways for epithelial ovarian cancer.Journal of ovarian research · 2024Article
- Cancer-associated fibroblast exosome LINC00355 promotes epithelial-mesenchymal transition and chemoresistance in colorectal cancer through the miR-34b-5p/CRKL axis.Cancer gene therapy · 2024Article
- RNA binding protein PRRC2B mediates translation of specific mRNAs and regulates cell cycle progression.Nucleic acids research · 2023Article
- Proteomic and functional characterization of intra-tumor heterogeneity in human endometrial cancer.Cell reports. Medicine · 2022Article
- A Fast and Easy Method for Specific Detection of Circular RNA by Rolling-Circle Amplification.Chembiochem : a European journal of chemical biology · 2020Article
- Copy number gains of the putative CRKL oncogene in laryngeal squamous cell carcinoma result in strong nuclear expression of the protein and influence cell proliferation and migration.Scientific reports · 2020Article
- CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell.BMC cancer · 2019Article
- MicroRNA-379 Suppresses Cervical Cancer Cell Proliferation and Invasion by Directly Targeting V-crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like (CRKL).Oncology research · 2018Article
- Expression of signaling adaptor proteins predicts poor prognosis in pancreatic ductal adenocarcinoma.Diagnostic pathology · 2017Article
- ABCG2 confers promotion in gastric cancer through modulating downstream CRKL in vitro combining with biostatistics mining.Oncotarget · 2017Article
- CRKL overexpression promotes cell proliferation and inhibits apoptosis in endometrial carcinoma.Oncology letters · 2017Article
- Crk-like adapter protein is overexpressed in cervical carcinoma, facilitates proliferation, invasion and chemoresistance, and regulates Src and Akt signaling.Oncology letters · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CRKL is an adapter protein which is overexpressed in many malignant tumors and plays crucial roles in tumor progression. However, expression pattern and biological roles of CRKL in pancreatic cancer have not been examined. In the present study, we found that CRKL expression in pancreatic cancer specimens was higher than that in normal pancreatic tissues. Colony formation assay and Matrigel invasion assay showed that the overexpression of CRKL in Bxpc3 and Capan2 cell lines with low endogenous expression increased cell proliferation and invasion. Flow cytometry showed that CRKL promoted cell proliferation by facilitating cell cycle. Further analysis of cell cycle- and invasion-related molecules showed that CRKL upregulated cyclin D1, cyclin A, matrix metalloproteinase 2 (MMP2) expression, and phosphorylated extracellular signal (ERK)-regulated kinase. In conclusion, our study demonstrated that CRKL was overexpressed in human pancreatic cancers and contributed to pancreatic cancer cell proliferation and invasion through ERK signaling.
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