ArticleBMC immunology2014
Primary immunodeficiency in infection-prone children in southern Sweden: occurrence, clinical characteristics and immunological findings.
Article in BMC immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Memory B Cells and Antibody Responses to Vaccines in Infected Children (MARVIC) With Recurrent Infections: Protocol for a Prospective Observational Study.JMIR research protocols · 2026Observational
- Immune Development in Early Life (IDEaL) longitudinal cohort study protocol: Identifying biomarkers of vaccine responsiveness, respiratory infection, and asthma.The journal of allergy and clinical immunology. Global · 2025Article
- Salivary polyreactive antibodies andThe European respiratory journal · 2024Article
- Image-Guided Percutaneous Drainage of Abdominal Abscesses in Pediatric Patients.Children (Basel, Switzerland) · 2024Review
- Antibody deficiencies in children are associated with prematurity and a family history of infections.Pediatric research · 2023Article
- Clinical Validation of a Primary Antibody Deficiency Screening Algorithm for Primary Care.Journal of clinical immunology · 2023Article
- The yin and the yang of early classical pathway complement disorders.Clinical and experimental immunology · 2022Review
- Childhood iron deficiency anemia leads to recurrent respiratory tract infections and gastroenteritis.Scientific reports · 2019Article
- Targeted screening for primary immunodeficiency disorders in the neonatal period and early infancy.African health sciences · 2019Article
- Evaluation of infectious and non-infectious complications in patients with primary immunodeficiency.Central-European journal of immunology · 2017Article
- Patient's Experience in Pediatric Primary Immunodeficiency Disorders: Computerized Classification of Questionnaires.Frontiers in immunology · 2017Article
- Primary immunodeficiency associated with chromosomal aberration - an ESID survey.Orphanet journal of rare diseases · 2016Article
- Novel treatment of severe combined immunodeficiency utilizing ex-vivo T-cell depleted haploidentical hematopoietic stem cell transplantation and CD45RA+ depleted donor lymphocyte infusions.Orphanet journal of rare diseases · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary immunodeficiency diseases (PIDs) comprise a heterogeneous group of disorders mainly characterized by increased susceptibility to infections. The aims of this study were to estimate the occurrence rate of PID in the paediatric (age ≤ 18 years) population of southern Sweden (approx. 265,000 children) and to describe their demographic, clinical and immunological characteristics. During a period of 4 years, in four paediatric speciality clinics in Skåne County in southern Sweden, children being seen for infections and fulfilling specific criteria were evaluated according to a predefined examination schedule. The initial analysis consisted of complete blood counts with analysis of lymphocyte subpopulations (T, B, NK cells), measurement of immunoglobulins (IgG, IgA, IgM, IgE and IgG subclasses), and assessment of the complement system (classical, alternative and lectin pathways). In addition, results of these immunological analyses in other children from the same area and time period were evaluated.
resultsIn total, 259 children (53.6% males) met the criteria and were included. The most common infection was recurrent otitis media. Immunological analyses results for about two thirds of the patients were outside age-related reference intervals. Further examination in this latter group identified 15 children with PID (9 males); 7 (2.7%) had genetically defined PID, representing 4 different diagnoses, and another 8 (3.1%) had a clinically defined PID - common variable immunodeficiency. No additional PID patient was identified from the evaluation of laboratory results in children not included in the study. The median age at diagnosis was 3.5 years (range 1-12 years).
conclusionsThe occurrence rate of PID was about 4 new cases per year in this population. Several different PID diagnoses were found, and the application of specified criteria to identify PID patients was useful. In children who are prone to infection, the use of a predefined set of immunological laboratory analyses at their first examination was beneficial for early identification of patients with PID.
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