ArticleJournal of Alzheimer's disease : JAD2015
Atlas-based diffusion tensor imaging correlates of executive function.
Article in Journal of Alzheimer's disease : JAD, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The application of diffusion tensor imaging in patients with mild cognitive impairment: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- White matter microstructural alterations in obstructive sleep apnea assessed by time-dependent diffusion MRI.Japanese journal of radiology · 2026Article
- Joint diffusional kurtosis magnetic resonance imaging analysis of white matter and the thalamus to identify subcortical ischemic vascular disease.Scientific reports · 2024Article
- White matter microstructure associations to amyloid burden in adults with Down syndrome.NeuroImage. Clinical · 2022Article
- Physical activity and cognitive and imaging biomarkers of Alzheimer's disease in down syndrome.Neurobiology of aging · 2021Article
- White matter microstructure associations with episodic memory in adults with Down syndrome: a tract-based spatial statistics study.Journal of neurodevelopmental disorders · 2021Article
- Development and validation of the Uniform Data Set (v3.0) executive function composite score (UDS3-EF).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Article
- Alpha desynchronization during simple working memory unmasks pathological aging in cognitively healthy individuals.PloS one · 2019Article
- Retained executive abilities in mild cognitive impairment are associated with increased white matter network connectivity.European radiology · 2018Article
- Utilization of MRI for Cerebral White Matter Injury in a Hypobaric Swine Model-Validation of Technique.Military medicine · 2017Article
- Dysexecutive syndrome in amnesic mild cognitive impairment: a multicenter study.BMC neurology · 2016Article
- Detection of changes in the periaqueductal gray matter of patients with episodic migraine using quantitative diffusion kurtosis imaging: preliminary findings.Neuroradiology · 2016Article
- Neuropsychiatric symptoms in Alzheimer's disease: What might be associated brain circuits?Molecular aspects of medicineReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Impairment in executive function (EF) is commonly found in Alzheimer's disease (AD) and mild cognitive impairment (MCI). Atlas-based diffusion tensor imaging (DTI) methods may be useful in relating regional integrity to EF measures in MCI and AD. Sixty-six participants (25 normal controls, 22 MCI, and 19 AD) received DTI scans and clinical evaluation. DTI scans were applied to a pre-segmented atlas and fractional anisotropy (FA) and mean diffusivity (MD) were calculated. ANOVA was used to assess group differences in frontal, parietal, and cerebellar regions. For regions differing between groups (p < 0.01), linear regression examined the relationship between EF scores and regional FA and MD. Anisotropy and diffusivity in frontal and parietal lobe white matter structures were associated with EF scores in MCI and only frontal lobe structures in AD. EF was more strongly associated with FA than MD. The relationship between EF and anisotropy and diffusivity was strongest in MCI. These results suggest that regional white matter integrity is compromised in MCI and AD and that FA may be a better correlate of EF than MD.
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