ArticleBMC pediatrics2014
Serum level of vitamin D and trace elements in children with recurrent wheezing: a cross-sectional study.
Article in BMC pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Association Between Circulating Zinc and Risk for Childhood Asthma and Wheezing: A Meta-analysis on 21 Articles and 2205 Children.Biological trace element research · 2024Pooled it
- Exposure to Heavy Metals and Allergic Outcomes in Children: a Systematic Review and Meta-analysis.Biological trace element research · 2022Pooled it
- Lower circulating zinc and selenium levels are associated with an increased risk of asthma: evidence from a meta-analysis.Public health nutrition · 2020Pooled it
- Cuproptosis of bronchial epithelial cells triggers airway remodeling in chronic asthma.Scientific reports · 2026Article
- Linking vitamin D levels with recurrent wheeze among Indian children.Bioinformation · 2026Article
- Research advance in correlation between childhood asthma and gut microbiota.Frontiers in cellular and infection microbiology · 2025Review
- Zinc Deficiency and Zinc Supplementation in Allergic Diseases.Biomolecules · 2024Review
- Association between dietary zinc intake and asthma in overweight or obese children and adolescents: A cross-sectional analysis of NHANES.The World Allergy Organization journal · 2024Article
- Article
- Copper homeostasis dysregulation in respiratory diseases: a review of current knowledge.Frontiers in physiology · 2024Review
- Predicting perinatal outcomes in women affected by COVID-19: An artificial intelligence (AI) approach.Journal of medicine and life · 2023Article
- Micronutrients and the Risk of Allergic Diseases in School Children.International journal of environmental research and public health · 2022Article
- The Role of Zinc in the Pathogenesis of Lung Disease.Nutrients · 2022Review
- A cross-sectional study on the effect of dietary zinc intake on the relationship between serum vitamin DFrontiers in nutrition · 2022Article
- Mineral Micronutrients in Asthma.Nutrients · 2021Review
- Serum zinc level and children`s asthma: A systematic and meta-analysis review article.Caspian journal of internal medicine · 2021Review
- Association between toenail zinc concentrations and incidence of asthma among American young adults: The CARDIA study.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2021Article
- Vitamin D and Immunity in Infants and Children.Nutrients · 2020Review
- The Role of Vitamin D Deficiency in Children With Recurrent Wheezing-Clinical Significance.Frontiers in pediatrics · 2020Review
- Predicting Asthma Using Clinical Indexes.Frontiers in pediatrics · 2019Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to show the relationship between recurrence of wheezing and serum levels of vitamin D, zinc, and copper in wheezy children compared with a healthy group.
methodsIn this cross sectional study, seventy-three children with wheezing and seventy-five controls were included without a follow-up period. The clinical characteristics of the children were assessed, the asthma predictive index and temporal pattern of wheeze were determined. The serum levels of vitamin D, zinc, and copper were measured. Pearson correlation analysis was used to evaluate the relationship between homogeneously distributed variables.
resultsThirty-two of the seventy-three children (43.8%) had more than three wheezing attacks (recurrent wheezing). The Asthma Predictive Index index was positive in 26 patients (35.6%). When classified to temporal pattern of wheeze, fifty-three of the study group (72.6%) had episodic wheezing and the remainder (27.4%) was classified as multiple-trigger wheezing. We found no overall significant difference between the study and control group in terms of vitamin D and trace elements . The vitamin D and zinc levels were significantly lower and serum copper and copper/zinc ratio was significantly higher in patients with recurrent wheezing (p =0.03, p <0.01, p =0.013, p <0.01, respectively) positive Asthma Predictive Index and multiple-trigger temporal pattern of wheeze compared with patients with non- recurrent wheezing, negative Asthma Predictive Index and episodic temporal pattern of wheeze.
conclusionIt may be postulated that for the determination of asthma risk in patients with recurrent wheezing, the serum level of vitamin D, copper and zinc can be used as a routine biomarker alongside the Asthma Predictive Index and temporal pattern of wheeze.
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