ArticleKidney international2015
The mortality risk with graft function has decreased among children receiving a first kidney transplant in the United States.
Article in Kidney international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06624358 (Physical Activity in Adolescents With Chronic Kidney Disease), which is not on this map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physical Activity in Adolescents With Chronic Kidney Disease
Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Management of Surgical Complications in Pediatric Kidney Transplantation.Journal of clinical medicine · 2026Review
- The role of sex differences in cardiovascular, metabolic, and immune functions in health and disease: a review for "Sex Differences in Health Awareness Day".Biology of sex differences · 2025Review
- Demographic Factors, Medication Adherence, and Post-transplant Health Outcomes: A Longitudinal Multilevel Modeling Approach.Journal of clinical psychology in medical settings · 2024Article
- Prediction of Outcomes After Heart Transplantation in Pediatric Patients Using National Registry Data: Evaluation of Machine Learning Approaches.JMIR cardio · 2023Article
- Epidemiology of pediatric chronic kidney disease/kidney failure: learning from registries and cohort studies.Pediatric nephrology (Berlin, Germany) · 2022Review
- An Integrated Transcriptomic Approach to Identify Molecular Markers of Calcineurin Inhibitor Nephrotoxicity in Pediatric Kidney Transplant Recipients.International journal of molecular sciences · 2021Article
- Follow-Up of Blood Pressure, Arterial Stiffness, and GFR in Pediatric Kidney Transplant Recipients.Frontiers in medicine · 2021Article
- Machine learning-based prediction of health outcomes in pediatric organ transplantation recipients.JAMIA open · 2021Article
- Death after Kidney Transplantation: An Analysis by Era and Time Post-Transplant.Journal of the American Society of Nephrology : JASN · 2020Article
- The Improving Renal Outcomes Collaborative: Blood Pressure Measurement in Transplant Recipients.Pediatrics · 2020Article
- Use of public health service increased risk kidneys in pediatric renal transplant recipients.Pediatric transplantation · 2019Article
- Survival in children requiring chronic renal replacement therapy.Pediatric nephrology (Berlin, Germany) · 2018Review
- The clinical epidemiology of young adults starting renal replacement therapy in the UK: presentation, management and survival using 15 years of UK Renal Registry data.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Article
- Factors associated with cardiovascular target organ damage in children after renal transplantation.Pediatric nephrology (Berlin, Germany) · 2017Article
- Cardiovascular risks in chronic kidney disease pediatric patients.Experimental and therapeutic medicine · 2017Article
- The impact of socioeconomic status and geographic remoteness on access to pre-emptive kidney transplantation and transplant outcomes among children.Pediatric nephrology (Berlin, Germany) · 2016Article
- Fibroblast growth factor-23 and chronic allograft injury in pediatric renal transplant recipients: a Midwest Pediatric Nephrology Consortium study.Pediatric transplantation · 2016Article
- Association of Body Mass Index with Patient-Centered Outcomes in Children with ESRD.Journal of the American Society of Nephrology : JASN · 2016Article
- Modernization of Chronic Allograft Injury Research: Better Biomarkers, Better Studies, Better Outcomes.Clinical transplants · 2015Article
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5 authors at 5 institutions in 2 countries.
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Abstract
Mortality has decreased in children with end-stage kidney disease. Decreases in mortality during dialysis and improved graft survival contributed to this improvement. However, it is unknown whether rates of death with graft function have also improved. We measured this in first transplant recipients under 21 years of age registered in the US Renal Data System. Cox models were used with a time-dependent renal replacement therapy modality variable to estimate the hazard ratios (HRs) for death with graft function associated with a 1-year increment in the calendar year of transplant. There were 157,201 person-years of observation among 17,468 recipients, with 82.2% of study time during graft function and 17.8% during dialysis after graft failure. There were 2003 deaths (12.7 deaths per 1000 person-years) overall, of which 985 occurred with graft function (7.6 deaths per 1000 person-years) and 1018 occurred during dialysis after graft failure (36.1 deaths per 1000 person-years). Each 1-year increment in calendar year of first transplant was associated with a significantly lower risk of death, both overall observation (HR 0.97 (0.96, 0.98)) and focusing on time with graft function (HR 0.98 (0.97, 0.99)). Living donation was significantly associated with better survival, whereas dialysis after graft failure was associated with a much higher mortality risk (HR 4.85 (4.40, 5.35)) compared with graft function. Thus, the risk of death with graft function has decreased in children receiving a first kidney transplant. Increasing living donation and minimizing dialysis may further improve outcomes.
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