ArticleBMC hematology2014
Thrombosis as a complication of central venous access in pediatric patients with malignancies: a 5-year single-center experience.
Article in BMC hematology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Central venous access device adverse events in pediatric patients with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- Trial
- Fluid Dynamic and in Vitro Blood Study to Understand Catheter-Related Thrombosis.Cardiovascular engineering and technology · 2025Article
- Numerical Study on the Impact of Central Venous Catheter Placement on Blood Flow in the Cavo-Atrial Junction.Annals of biomedical engineering · 2024Article
- Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience.Acta medica academica · 2023Article
- Open versus Transcutaneous (Ultrasound-Guided and Based on Anatomic Landmarks) Tunneled Venous Access to the Right Internal Jugular Vein in Children: A Prospective Single-Center Study.Diseases (Basel, Switzerland) · 2023Article
- Cost-utility analysis of different venous access devices in breast cancer patients: a decision-based analysis model.BMC health services research · 2023Article
- Risk factors for totally implantable access ports-associated thrombosis in pediatric oncology patients.Scientific reports · 2023Article
- Percutaneous implantation of peripherally inserted totally implantable venous access systems in the forearm in adolescent patients.Pediatric radiology · 2022Article
- Thromboembolic events in metastatic testicular cancer treated with cisplatin-based chemotherapy.World journal of clinical oncology · 2021Article
- Central Venous Access Devices (CVAD) in Pediatric Oncology Patients-A Single-Center Retrospective Study Over More Than 9 Years.Frontiers in pediatrics · 2019Article
- Tuberculosis in children presenting with chylothorax - Report of two cases and review of the literature.Respiratory medicine case reports · 2019Article
- Identification of catheter misplacement in early port CVC dysfunction.Contemporary oncology (Poznan, Poland) · 2018Article
- Spontaneous coiling of the distal tip of the chemotherapy port.Medical journal of the Islamic Republic of Iran · 2018Article
- Article
- [The incidence and risk factors of catheter-related-thrombosis during induction chemotherapy in acute lymphocytic leukemia children].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2017Article
- Innate Immunity and Biomaterials at the Nexus: Friends or Foes.BioMed research international · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReliable central venous access (CVC) is essential for hematology-oncology patients since frequent puncture of peripheral veins-e.g., for chemotherapy, antibiotic administration, repeated blood sampling, and monitoring-can cause unacceptable pain and psychological trauma, as well as severe side effects in cases of extravasation of chemotherapy drugs. However, CVC lines still carry major risk factors, including thrombosis, infection (e.g., entry site, tunnel, and luminal infections), and catheter dislocation, leakage, or breakage.
methodsHere we performed a retrospective database analysis to determine the incidence of CVC-associated thrombosis in a single-center cohort of 448 pediatric oncologic patients, and to analyze whether any subgroup of patients was at increased risk and thus might benefit from prophylactic anticoagulation.
resultsOf the 448 patients, 269 consecutive patients received a CVC, and 55 of these 269 patients (20%) also had a thrombosis. Of these 55 patients, 43 had at least one CVC-associated thrombosis (total number of CVC-associated thrombosis: n = 52). Among all patients, the median duration of CVC exposure was 464 days. Regarding exposure time, no significant difference was found between patients with and without CVC-associated thrombosis. Subclavia catheters and advanced tumor stages seem to be the main risk factors for the development of CVC-associated thrombosis, whereas pharmacologic prophylaxis did not seem to have a relevant impact on the rate of thrombosis.
conclusionsWe conclude that pediatric surgeons and oncologists should pay close attention to ensuring optimal and accurate CVC placement, as this appears the most effective tool to minimize CVC-associated complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.