Evidence map›Paper›PMID 25317237›Full record

ReviewWorld journal of diabetes2014

Hepatitis C virus infection and type 1 and type 2 diabetes mellitus.

Alessandro Antonelli, Silvia Martina Ferrari, Dilia Giuggioli, Andrea Di Domenicantonio, Ilaria Ruffilli, Alda Corrado, Silvia Fabiani, Santino Marchi, Clodoveo Ferri, Ele Ferrannini and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of diabetes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. The double burden of diabetes and global infection in low and middle-income countries.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2019
    Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Metabolic complications of hepatitis C virus infection.World journal of gastroenterology · 2021
    Review
  17. Article
  18. Review
  19. Association between hepatitis C antiviral treatment and diabetes mellitus: A case series.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alessandro AntonelliAlessandro Antonelli, Silvia Martina Ferrari, Andrea Di Domenicantonio, Ilaria Ruffilli, Alda Corrado, Silvia Fabiani, Ele Ferrannini, Poupak Fallahi, Department of Clinical and Experimental Medicine, University of Pisa, I-56126 Pisa, Italy.
Silvia Martina FerrariAlessandro Antonelli, Silvia Martina Ferrari, Andrea Di Domenicantonio, Ilaria Ruffilli, Alda Corrado, Silvia Fabiani, Ele Ferrannini, Poupak Fallahi, Department of Clinical and Experimental Medicine, University of Pisa, I-56126 Pisa, Italy.
Dilia GiuggioliAlessandro Antonelli, Silvia Martina Ferrari, Andrea Di Domenicantonio, Ilaria Ruffilli, Alda Corrado, Silvia Fabiani, Ele Ferrannini, Poupak Fallahi, Department of Clinical and Experimental Medicine, University of Pisa, I-56126 Pisa, Italy.
Andrea Di DomenicantonioAlessandro Antonelli, Silvia Martina Ferrari, Andrea Di Domenicantonio, Ilaria Ruffilli, Alda Corrado, Silvia Fabiani, Ele Ferrannini, Poupak Fallahi, Department of Clinical and Experimental Medicine, University of Pisa, I-56126 Pisa, Italy.
Ilaria RuffilliAlessandro Antonelli, Silvia Martina Ferrari, Andrea Di Domenicantonio, Ilaria Ruffilli, Alda Corrado, Silvia Fabiani, Ele Ferrannini, Poupak Fallahi, Department of Clinical and Experimental Medicine, University of Pisa, I-56126 Pisa, Italy.
Alda CorradoAlessandro Antonelli, Silvia Martina Ferrari, Andrea Di Domenicantonio, Ilaria Ruffilli, Alda Corrado, Silvia Fabiani, Ele Ferrannini, Poupak Fallahi, Department of Clinical and Experimental Medicine, University of Pisa, I-56126 Pisa, Italy.
Silvia FabianiAlessandro Antonelli, Silvia Martina Ferrari, Andrea Di Domenicantonio, Ilaria Ruffilli, Alda Corrado, Silvia Fabiani, Ele Ferrannini, Poupak Fallahi, Department of Clinical and Experimental Medicine, University of Pisa, I-56126 Pisa, Italy.
Santino MarchiAlessandro Antonelli, Silvia Martina Ferrari, Andrea Di Domenicantonio, Ilaria Ruffilli, Alda Corrado, Silvia Fabiani, Ele Ferrannini, Poupak Fallahi, Department of Clinical and Experimental Medicine, University of Pisa, I-56126 Pisa, Italy.
Clodoveo FerriAlessandro Antonelli, Silvia Martina Ferrari, Andrea Di Domenicantonio, Ilaria Ruffilli, Alda Corrado, Silvia Fabiani, Ele Ferrannini, Poupak Fallahi, Department of Clinical and Experimental Medicine, University of Pisa, I-56126 Pisa, Italy.
Ele FerranniniAlessandro Antonelli, Silvia Martina Ferrari, Andrea Di Domenicantonio, Ilaria Ruffilli, Alda Corrado, Silvia Fabiani, Ele Ferrannini, Poupak Fallahi, Department of Clinical and Experimental Medicine, University of Pisa, I-56126 Pisa, Italy.
Poupak FallahiAlessandro Antonelli, Silvia Martina Ferrari, Andrea Di Domenicantonio, Ilaria Ruffilli, Alda Corrado, Silvia Fabiani, Ele Ferrannini, Poupak Fallahi, Department of Clinical and Experimental Medicine, University of Pisa, I-56126 Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis C virus (HCV) infection and diabetes mellitus are two major public health problems that cause devastating health and financial burdens worldwide. Diabetes can be classified into two major types: type 1 diabetes mellitus (T1DM) and T2DM. T2DM is a common endocrine disorder that encompasses multifactorial mechanisms, and T1DM is an immunologically mediated disease. Many epidemiological studies have shown an association between T2DM and chronic hepatitis C (CHC) infection. The processes through which CHC is associated with T2DM seem to involve direct viral effects, insulin resistance, proinflammatory cytokines, chemokines, and other immune-mediated mechanisms. Few data have been reported on the association of CHC and T1DM and reports on the potential association between T1DM and acute HCV infection are even rarer. A small number of studies indicate that interferon-α therapy can stimulate pancreatic autoimmunity and in certain cases lead to the development of T1DM. Diabetes and CHC have important interactions. Diabetic CHC patients have an increased risk of developing cirrhosis and hepatocellular carcinoma compared with non-diabetic CHC subjects. However, clinical trials on HCV-positive patients have reported improvements in glucose metabolism after antiviral treatment. Further studies are needed to improve prevention policies and to foster adequate and cost-effective programmes for the surveillance and treatment of diabetic CHC patients.

Indexed as

EpidemiologyHepatitis C virus infectionPathogenesisPreventionTreatmentType 1 diabetes mellitusType 2 diabetes mellitus

Identifiers

PMID25317237
PMCPMC4138583

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.