Evidence map›Paper›PMID 25317109›Full record

ReviewGenomics & informatics2014

Regulation and function of the peg3 imprinted domain.

Hongzhi He, Joomyeong Kim

Abstract readReview
In one paragraph

Review in Genomics & informatics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
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  3. Roles of retrovirus-derivedFrontiers in cell and developmental biology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hongzhi HeDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
Joomyeong KimDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.

Funding

Imprinting studies of a paternally expressed Usp29 geneR01GM066225 · NIGMS · UNIVERSITY OF CALIF-LAWRNC LVRMR NAT LAB · PI KIM, JOOMYEONG · 2004 to 2013
$2.6M
Aebp2 as an epigenetic regulator for neural crest cellR01GM097074 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI KIM, JOOMYEONG · 2013 to 2016
$1.1M
NIGMS NIH HHS R01 GM066225NIGMS NIH HHS R01 GM097074
6 · The paper itself

Abstract

A subset of mammalian genes differ functionally between two alleles due to genomic imprinting, and seven such genes (Peg3, Usp29, APeg3, Zfp264, Zim1, Zim2, Zim3) are localized within the 500-kb genomic interval of the human and mouse genomes, constituting the Peg3 imprinted domain. This Peg3 domain shares several features with the other imprinted domains, including an evolutionarily conserved domain structure, along with transcriptional co-regulation through shared cis regulatory elements, as well as functional roles in controlling fetal growth rates and maternal-caring behaviors. The Peg3 domain also displays some unique features, including YY1-mediated regulation of transcription and imprinting; conversion and adaptation of several protein-coding members as ncRNA genes during evolution; and its close connection to human cancers through the potential tumor suppressor functions of Peg3 and Usp29. In this review, we summarize and discuss these features of the Peg3 domain.

Indexed as

genomic imprintingncRNAPeg3tumor suppressor genesYY1 transcription factor

Identifiers

PMID25317109
PMCPMC4196374

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.