ArticleThe International journal of angiology : official publication of the International College of Angiology, Inc2014
Ascending thoracic aortic aneurysms protect against myocardial infarctions.
Article in The International journal of angiology : official publication of the International College of Angiology, Inc, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Diabetes is not a negative prognostic factor for 30-days mortality after surgery for acute type A aortic dissection.Cardiovascular endocrinology & metabolism · 2024Article
- Evidence Accumulates: Patients with Ascending Aneurysms Are Strongly Protected from Atherosclerotic Disease.International journal of molecular sciences · 2023Review
- "Big Data" Analyses Underlie Clinical Discoveries at the Aortic Institute.The Yale journal of biology and medicine · 2023Review
- Risk Factors for Mortality From Aortic Aneurysm and Dissection: Results From a 26-Year Follow-Up of a Community-Based Population.Journal of the American Heart Association · 2023Article
- Article
- Coronary artery disease in aortic aneurysm and dissection.Indian journal of thoracic and cardiovascular surgery · 2022Article
- Extent of Coronary Artery Disease in Patients With Stenotic Bicuspid Versus Tricuspid Aortic Valves.Journal of the American Heart Association · 2021Observational
- Stanford type B aortic dissection is more frequently associated with coronary artery atherosclerosis than type A.Journal of cardiothoracic surgery · 2018Article
- Ascending Aortic Proaneurysmal Genetic Mutations with Antiatherogenic Effects.The International journal of angiology : official publication of the International College of Angiology, Inc · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been increasing evidence that ascending thoracic aortic aneurysms (TAAs) protect against atherosclerosis. However, there have been no studies examining the relationship between ascending TAAs and clinical endpoints of atherosclerosis, such as stroke or peripheral arterial disease. In this study, we aim to characterize the relationship between TAAs and a specific clinical endpoint of atherosclerosis, myocardial infarction (MI). We compared prevalence of coronary artery disease (CAD) and MIs in 487 patients who underwent surgical repair for ascending TAAs to 500 control patients who did not have an ascending TAA. Multivariate binary logistic regression was used to calculate the odds of having MI if a patient had an ascending TAA versus any of several MI risk factors. There was a significantly lower prevalence of CAD and MI in the ascending TAA group than in the control TAA group. The odds of having a MI if a patient had a MI risk factor were all > 1 (more likely to have a MI), with the lowest statistically significant odds ratio being 1.54 (age; p = 0.001) and the highest being 14.9 (family history of MI; p < 0.001). The odds ratio of having a MI if a patient had an ascending TAA, however, was near 0 at 0.05 (p < 0.001). This study provides evidence that ascending TAAs protect against MIs, adding further support to the hypothesis that ascending TAAs protect against atherosclerotic disease.
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