ArticleJournal of basic and clinical pharmacy2014
Evaluation of sub-chronic toxic effects of petroleum ether, a laboratory solvent in Sprague-Dawley rats.
Article in Journal of basic and clinical pharmacy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 23 citations in OpenAlex.
- Quantitative analysis of ethylene precursor ACC in plant samples by liquid chromatography-tandem mass spectrometry.BMC plant biology · 2025Article
- Methods of Protein Extraction from House Crickets (Foods (Basel, Switzerland) · 2025Article
- From Sharks to Yeasts: Squalene in the Development of Vaccine Adjuvants.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Acute and sub-chronic toxicity of tetrandrine in intravenously exposed female BALB/c mice.Chinese journal of integrative medicine · 2016Article
- Ameliorative Effect of Curcumin on Olanzapine-induced Obesity in Sprague-Dawley Rats.Pharmacognosy researchArticle
- Pulmonary Toxicity Induced by N-Hexane in Wistar Male Rats After Oral Subchronic Exposure.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn general, organic solvents are inhibiting many physiological enzymes and alter the behavioural functions, but the available scientific knowledge on laboratory solvent induced organ specific toxins are very limited. Hence, the present study was planned to determine the sub-chronic toxic effects of petroleum ether (boiling point 40-60°C), a laboratory solvent in Sprague-Dawley (SD) rats. MATERIALS AND
methodsThe SD rats were divided into three different groups viz., control, low exposure petroleum ether (250 mg/kg; i.p.) and high exposure petroleum ether (500 mg/kg; i.p.) administered group. The animals were exposed with petroleum ether once daily for 2 weeks. Prior to the experiment and end of the experiment animals behaviour, locomotor and memory levels were monitored. Before initiating the study animals were trained for 2 weeks for its learning process and its memory levels were evaluated. Body weight (BW) analysis, locomotor activity, anxiogenic effect (elevated plus maze) and learning and memory (Morris water navigation task) were monitored at regular intervals. On 14(th) day of the experiment, few ml of blood sample was collected from all the experimental animals for estimation of biochemical parameters. At the end of the experiment, all the animals were sacrificed, and brain, liver, heart, and kidney were collected for biochemical and histopathological analysis.
resultsIn rats, petroleum ether significantly altered the behavioural functions; reduced the locomotor activity, grip strength, learning and memory process; inhibited the regular body weight growth and caused anxiogenic effects. Dose-dependent organ specific toxicity with petroleum ether treated group was observed in brain, heart, lung, liver, and kidney. Extrapyramidal effects that include piloerection and cannibalism were also observed with petroleum ether administered group. These results suggested that the petroleum ether showed a significant decrease in central nervous system (CNS) activity, and it has dose-dependent toxicity on all vital organs.
conclusionThe dose-dependent CNS and organ specific toxicity was observed with sub-chronic administration of petroleum ether in SD rats.
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