Evidence map›Paper›PMID 25316716›Full record

ArticleJournal of diabetes science and technology2014

A novel method to detect pressure-induced sensor attenuations (PISA) in an artificial pancreas.

Nihat Baysal, Fraser Cameron, Bruce A Buckingham, Darrell M Wilson, H Peter Chase, David M Maahs, B Wayne Bequette, In Home Closed-Loop Study Group (IHCL)

Open access · bronzeAbstract read
In one paragraph

Article in Journal of diabetes science and technology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Metabolic Models, in Silico Trials, and Algorithms.Diabetes technology & therapeutics · 2025
    Review
  7. Metabolic Models, in Silico Trials, and Algorithms.Journal of diabetes science and technology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Continuous Glucose Monitoring in the Hospital.Endocrinology and metabolism (Seoul, Korea) · 2021
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nihat BaysalDepartment of Chemical & Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA baysan@rpi.edu.
Fraser CameronDepartment of Chemical & Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.
Bruce A BuckinghamDivision of Pediatric Endocrinology and Diabetes, Stanford University, Stanford, CA, USA.
Darrell M WilsonDivision of Pediatric Endocrinology and Diabetes, Stanford University, Stanford, CA, USA.
H Peter ChaseBarbara Davis Center for Childhood Diabetes, Aurora, CO, USA.
David M MaahsBarbara Davis Center for Childhood Diabetes, Aurora, CO, USA.
B Wayne BequetteDepartment of Chemical & Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.
In Home Closed-Loop Study Group (IHCL)
Rensselaer Polytechnic Institute · USStanford University · US

Funding

In home closed loop reduction of nocturnal hypoglycemia and daytime hyperglycemiaR01DK085591 · NIDDK · JAEB CENTER FOR HEALTH RESEARCH, INC. · PI BECK, ROY W., BUCKINGHAM, BRUCE A · 2009 to 2013
$3.9M
NIDDK NIH HHS R01 DK085591NIDDK NIH HHS R01DK085591
6 · The paper itself

Abstract

Continuous glucose monitors (CGMs) provide real-time interstitial glucose concentrations that are essential for automated treatment of individuals with type 1 diabetes. Miscalibration, noise spikes, dropouts, or pressure applied to the site (e.g., lying on the site while sleeping) can cause inaccurate glucose signals, which could lead to inappropriate insulin dosing decisions. These studies focus on the problem of pressure-induced sensor attenuations (PISAs) that occur overnight and can cause undesirable pump shut-offs in a predictive low glucose suspend system. The algorithm presented here uses real-time CGM readings without knowledge of meals, insulin doses, activity, sensor recalibrations, or fingerstick measurements. The real-time PISA detection technique was tested on outpatient "in-home" data from a predictive low-glucose suspend trial with over 1125 nights of data. A total of 178 sets were created by using different parameters for the PISA detection algorithm to illustrate its range of available performance. The tracings were reviewed via a web-based analysis tool by an engineer with an extensive expertise on analyzing clinical datasets and ~3% of the CGM readings were marked as PISA events which were used as the gold standard. It is shown that 88.34% of the PISAs were successfully detected by the algorithm, and the percentage of false detections could be reduced to 1.70% by altering the algorithm parameters. Use of the proposed PISA detection method can result in a significant decrease in undesirable pump suspensions overnight, and may lead to lower overnight mean glucose levels while still achieving a low risk of hypoglycemia.

Indexed as

AlgorithmsPancreas, ArtificialBlood GlucoseBlood Glucose Self-MonitoringHumansPressureBlood Glucosealgorithmsartificial pancreascontinuous glucose monitorfault detectionhypoglycemiasensor attenuations

Identifiers

PMID25316716
PMCPMC4455457
OpenAlexW2110670476

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.