ArticleMolecular & cellular proteomics : MCP2015
cysTMTRAQ-An integrative method for unbiased thiol-based redox proteomics.
Article in Molecular & cellular proteomics : MCP, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- Defining and refining the cysteine redoxome through sulfur chemical biology.Nature chemical biology · 2026Review
- Melatonin promotes stomatal immunity by mediating phytohormone crosstalk inFrontiers in plant science · 2026Article
- More questions than answers: insights into potential cysteine-rich receptor-like kinases redox signalling in Arabidopsis.The Plant journal : for cell and molecular biology · 2025Review
- The impact of light and thioredoxins on the plant thiol-disulfide proteome.Plant physiology · 2024Article
- Cys-SH based quantitative redox proteomics of salt induced response in sugar beet monosomic addition line M14.Botanical studies · 2021Article
- Contemporary proteomic strategies for cysteine redoxome profiling.Plant physiology · 2021Review
- Proteomic Approaches to Study Cysteine Oxidation: Applications in Neurodegenerative Diseases.Frontiers in molecular neuroscience · 2021Review
- Redox Systems Biology: Harnessing the Sentinels of the Cysteine Redoxome.Antioxidants & redox signaling · 2020Review
- S-Nitroso-Proteome Revealed in Stomatal Guard Cell Response to Flg22.International journal of molecular sciences · 2020Article
- Activity-Based Sensing for Site-Specific Proteomic Analysis of Cysteine Oxidation.Accounts of chemical research · 2020Review
- oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening.Redox biology · 2019Article
- Comprehensive Redox Profiling of the Thiol Proteome ofMolecular & cellular proteomics : MCP · 2018Article
- Characterization of thiol-based redox modifications ofFEBS open bio · 2018Article
- Thiol Based Redox Signaling in Plant Nucleus.Frontiers in plant science · 2018Review
- Absence ofFrontiers in molecular neuroscience · 2018Article
- Bicarbonate Induced Redox Proteome Changes in Arabidopsis Suspension Cells.Frontiers in plant science · 2017Article
- Proteomic approaches to quantify cysteine reversible modifications in aging and neurodegenerative diseases.Proteomics. Clinical applications · 2016Review
- Comparative Proteomic Analysis of Soybean Leaves and Roots by iTRAQ Provides Insights into Response Mechanisms to Short-Term Salt Stress.Frontiers in plant science · 2016Article
- Protein Phosphorylation and Redox Modification in Stomatal Guard Cells.Frontiers in physiology · 2016Review
- Quantifying reversible oxidation of protein thiols in photosynthetic organisms.Journal of the American Society for Mass Spectrometry · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Protein redox regulation plays important roles in many biological processes. Protein cysteine thiols are sensitive to redox changes and may function as redox switches, which turn signaling and metabolic pathways on or off to ensure speedy responses to environmental stimuli or stresses. Here we report a novel integrative proteomics method called cysTMTRAQ that combines two types of isobaric tags, cysteine tandem mass tags and isobaric tag for relative and absolute quantification, in one experiment. The method not only enables simultaneous analysis of cysteine redox changes and total protein level changes, but also allows the determination of bona fide redox modified cysteines in proteins through the correction of protein turnover. Overlooking the factor of protein-level changes in the course of protein posttranslational modification experiments could lead to misleading results. The capability to analyze protein posttranslational modification dynamics and protein-level changes in one experiment will advance proteomic studies in many areas of biology and medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.