Can limited scientific value of potential pandemic pathogen experiments justify the risks?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

9 citing papers in PubMed.

1. Dual-use artificial intelligence and biology: upstream risk-benefit reviews.Frontiers in microbiology · 2026
   Article
2. Application of a Biologically Contained Reporter System To Study Gain-of-Function H5N1 Influenza A Viruses with Pandemic Potential.mSphere · 2020
   Article
3. Ethical and Philosophical Considerations for Gain-of-Function Policy: The Importance of Alternate Experiments.Frontiers in bioengineering and biotechnology · 2018
   Article
4. Why Do Exceptionally Dangerous Gain-of-Function Experiments in Influenza?Methods in molecular biology (Clifton, N.J.) · 2018
   Review
5. Evidence for history-dependence of influenza pandemic emergence.Scientific reports · 2017
   Article
6. Mapping influenza transmission in the ferret model to transmission in humans.eLife · 2015
   Article
7. Assessing and Managing the Risks of Potential Pandemic Pathogen Research.mBio · 2015
   Article
8. Gain-of-function experiments: time for a real debate.Nature reviews. Microbiology · 2015
   Review
9. Reply to "Can limited scientific value of potential pandemic pathogen experiments justify the risks?".mBio · 2014
   Article

Corrections and comments

• Commented on by
  Reply to "Can limited scientific value of potential pandemic pathogen experiments justify the risks?".2014
• Comment on
  An epistemological perspective on the value of gain-of-function experiments involving pathogens with pandemic potential.2014

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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