Evidence map›Paper›PMID 25316523›Full record

ArticleJournal of hematology & oncology2014

CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia.

Yajuan Cui, Bing Li, Robert Peter Gale, Qian Jiang, Zefeng Xu, Tiejun Qin, Peihong Zhang, Yue Zhang, Zhijian Xiao

Open access · goldAbstract readLetter
In one paragraph

Article in Journal of hematology & oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Current Management of Chronic Neutrophilic Leukemia.Current treatment options in oncology · 2021
    Review
  6. Article
  7. Article
  8. Article
  9. [Ruxolitinib for chronic neutrophilic leukemia: a case report and literature review].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2018
    Article
  10. Targeted next-generation sequencing identifies clinically relevant mutations in patients with chronic neutrophilic leukemia at diagnosis and blast crisis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2018
    Article
  11. Review
  12. Chronic neutrophilic leukemia.Proceedings (Baylor University. Medical Center) · 2018
    Article
  13. Review
  14. Review
  15. Somatic SETBP1 mutations in myeloid neoplasms.International journal of hematology · 2017
    Review
  16. Article
  17. Article
  18. Review
  19. The Mutation Profile of Calreticulin in Patients with Myeloproliferative Neoplasms and Acute Leukemia.Turkish journal of haematology : official journal of Turkish Society of Haematology · 2016
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yajuan Cui
Bing Li
Robert Peter Gale
Qian Jiang
Zefeng Xu
Tiejun Qin
Peihong Zhang
Yue Zhang
Zhijian XiaoMDS and MPN Centre, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, China. zjxiao@medmail.com.cn.
Institute of Hematology & Blood Diseases Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNImperial College London · GBPeking University People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The WHO 2008 definition of chronic neutrophilic leukemia (CNL) is based on clinical and laboratory parameters but not on molecular abnormalities. Mutations in CSF3R, SETBP1 and CALR are reported in patients with chronic neutrophilic leukemia (CNL). However, because CNL is rare, there are few large studies of this issue. We sequenced these genes in 14 patients who met the WHO-criteria of CNL. 8 subjects had CSF3R(T618I), 6 SETBP1 mutations and 1 a CALR mutation. Our data suggest mutation analysis of CSF3R, SETBP1 and CALR should be included in the diagnostic criteria for CNL. These data may also have therapy implications.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorCalreticulinCarrier ProteinsDNA Mutational AnalysisFemaleHumansLeukemia, Neutrophilic, ChronicMaleMiddle AgedMutationNuclear ProteinsPolymerase Chain ReactionReceptors, Colony-Stimulating FactorBiomarkers, TumorCalreticulinCALR protein, humanCarrier ProteinsCSF3R protein, humanNuclear ProteinsReceptors, Colony-Stimulating FactorSETBP1 protein, human

Identifiers

PMID25316523
PMCPMC4200198
OpenAlexW2171630203

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.