ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging
Jugular Venous Flow Abnormalities in Multiple Sclerosis Patients Compared to Normal Controls.
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Clinical Classification and Collateral Circulation in Chronic Cerebrospinal Venous Insufficiency.Frontiers in neurology · 2020Article
- Internal jugular vein stenosis induced by tortuous internal carotid artery compression: two case reports and literature review.The Journal of international medical research · 2019Review
- Transient Global Amnesia Linked to Impairment of Brain Venous Drainage: An Ultrasound Investigation.Frontiers in neurology · 2019Article
- Five-Year Longitudinal Study of Neck Vessel Cross-Sectional Area in Multiple Sclerosis.AJNR. American journal of neuroradiology · 2018Article
- Spatial distribution of flow and oxygenation in the cerebral venous drainage system.Journal of magnetic resonance imaging : JMRI · 2018Article
- Age differences in arterial and venous extra-cerebral blood flow in healthy adults: contributions of vascular risk factors and genetic variants.Brain structure & function · 2017Article
- Jugular Anomalies in Multiple Sclerosis Are Associated with Increased Collateral Venous Flow.AJNR. American journal of neuroradiology · 2017Article
- Delay of late-venous phase cortical vein filling in acute ischemic stroke patients: Associations with collateral status.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Extracranial Venous abnormalities: A true pathological finding in patients with multiple sclerosis or an anatomical variant?European radiology · 2017Article
- Lack of correlation between extracranial venous abnormalities and multiple sclerosis: a quantitative MRI study.The British journal of radiology · 2016Article
- Internal Jugular Vein Cross-Sectional Area Enlargement Is Associated with Aging in Healthy Individuals.PloS one · 2016Article
- Article
- Cerebral venous collaterals: A new fort for fighting ischemic stroke?Progress in neurobiologyReview
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTo determine if extracranial venous structural and flow abnormalities exist in patients with multiple sclerosis (MS).
methodsMagnetic resonance imaging was used to assess the anatomy and function of major veins in the neck in 138 MS patients and 67 healthy controls (HC). Time-of-flight MR angiography (MRA) was used to assess stenosis while 2-dimensional phase-contrast flow quantification was used to assess flow at the C2/C3 and C5/C6 levels. Venous flow was normalized to the total arterial flow. The MS patients were divided into stenotic (ST) and nonstenotic (NST) groups based on MRA assessment, and each group was compared to the HC group in anatomy and flow.
resultsThe MS group showed lower normalized internal jugular vein (IJV) blood flow (tIJV/tA) than the HC group (P < .001). In the MS group, 72 (52%) were classified as ST while 66 (48%) were NST. In the HC group, 11 (23%) were ST while 37 (77%) were NST. The ST-MS group had lower IJV flow than both HC and NST-MS groups.
conclusionAfter categorizing the MS population into two groups based upon anatomical stenosis, as determined from an absolute quantification of IJV cross section, clear differences in IJV flow between the ST-MS and HC samples became evident. Despite the unknown etiology of MS, abnormal venous flow was noted in a distinct group of MS patients compared to HC.
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