ArticleSaudi medical journal2014
Assessment of low vitamin D among Saudi Arabians. Did we overshoot the runway?
Article in Saudi medical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Efficacy and Safety of 22-Oxa-Calcitriol in Patients with Rheumatoid Arthritis: A Phase II Trial.Medical science monitor : international medical journal of experimental and clinical research · 2018Trial
- Vitamin D Nutritional Status in the Middle East and North Africa Region: A Systematic Review and Meta-analysis.Current developments in nutrition · 2025Article
- Knowledge and behaviors of using vitamin D to boost immunity against COVID-19 pandemic: A cross-sectional study in Saudi Arabia.Medicine · 2022Article
- The Association between Vitamin D Hypovitaminosis and Cardiovascular Disease Risk in Saudi Diabetic Patients Type II.Biochemistry research international · 2022Article
- Variations in 25-Hydroxyvitamin D in Countries from the Middle East and Europe: The Roles of UVB Exposure and Diet.Nutrients · 2019Article
- Plasma 25-Hydroxy Vitamin D Is Not Associated with Either Cognitive Function or Academic Performance in Adolescents.Nutrients · 2018Article
- Prevalence of musculoskeletal pain in association with serum 25-hydroxyvitamin D concentrations in patients with type 2 diabetes mellitus.Biomedical reports · 2018Article
- The association of adiposity, physical fitness, vitamin D levels and haemodynamic parameters in young Saudi females.Journal of Taibah University Medical Sciences · 2018Article
- Vitamin D status correction in Saudi Arabia: an experts' consensus under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases (ESCEO).Archives of osteoporosis · 2017Article
- Genetic influence on circulating vitamin D among Saudi Arabians.Saudi medical journal · 2016Observational
- The Association of Adiposity Indices and Plasma Vitamin D in Young Females in Saudi Arabia.International journal of endocrinology · 2016Article
- Parathyroid Glands response to Low Vitamin D levels in Healthy Adults: A Cross-Sectional Study.The Ulster medical journal · 2015Article
- Vitamin D and iron deficiencies among Saudi children and adolescents: A persistent problem in the 21Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
- Vitamin D deficiency in Saudi Arabians: A reality or simply hype: A meta-analysis (2008-2015).Journal of family & community medicineReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare the performance of 3 commonly used 25-hydroxyvitamin D (25-OHD) assays among a sample of the Saudi population.
methodsThis cross-sectional study was carried out between January 2011 and December 2012 at King Fahd Hospital of the University, Al-Khobar, Saudi Arabia. After informed consent, blood samples for measurement of 25-OHD level was extracted from 200 adults. The vitamin D levels of each individual were determined using chemiluminescence immunoassay (CLIA), radio-immuno assay (RIA), and liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay. Assays were also compared through commonly used cut-points for classification of vitamin D deficiency. Bias between assays was evaluated using Bland-Altman plots.
resultsThe average age of patients was 45.7+/-16.1 years. A significant difference between the assays was found. The mean 25-OHD levels were highest for the LC-MS/MS (21.65 ng/mL, 95% CI 19.74-23.56), intermediate for RIA (16.607 ng/mL, 95% CI 14.87-18.32), and lowest for CLIA method (13.864 ng/mL, 95% CI 12.109-15.618). Using 30 ng/mL as a cutoff value, only 6% was found to have normal levels of 25-OHD using CLIA, 9% using RIA, and 22% using LC-MS/MS.
conclusionLevels of 25-OHD and the prevalence of vitamin D deficiency are dependent on the assay used. The reported high prevalence of hypovitaminosis D among the Saudi population can be partially explained by the use of assays that underestimate vitamin D levels.
Indexed as
Identifiers
25316470PMC4362109W1552040126What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.