Evidence map›Paper›PMID 25316464›Full record

Trial reportSaudi medical journal2014

Evaluation of adjunctive systemic doxycycline with non-surgical periodontal therapy within type 2 diabetic patients.

Abeer M Al-Nowaiser, Hamad Al-Zoman, Jagan K Baskaradoss, Asirvatham A Robert, Khalid H Al-Zoman, Abdulaziz M Al-Sohail, Abdulaziz S Al-Suwyed, Sebastian G Ciancio, Sultan A Al-Mubarak

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC
In one paragraph

Trial report in Saudi medical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 4 pooled it
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Abeer M Al-NowaiserDepartment of Preventive Dental Sciences, King Abdulaziz University, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Hamad Al-Zoman
Jagan K Baskaradoss
Asirvatham A Robert
Khalid H Al-Zoman
Abdulaziz M Al-Sohail
Abdulaziz S Al-Suwyed
Sebastian G Ciancio
Sultan A Al-Mubarak
King Abdulaziz University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the effects of systemic doxycycline on clinical and microbiological parameters of diabetic subjects with chronic periodontitis.

methodsThis 9-month multi-center, randomized, parallel, single-blinded study was conducted from different hospitals in Riyadh, Saudi Arabia between April 2010 and December 2010. A total of 76 diabetic subjects with chronic periodontitis were randomized into 2 groups: control group (CG) received only scaling and root planing (SRP), and the treatment group (TG) receiving systemic doxycycline during the reevaluation visit 45 days after the completion of SRP. Probing pocket depth, clinical attachment level, gingival index, plaque index, and bleeding on probing were collected at baseline, 45 days after SRP, and one, 3, and 6 months  after the use of systemic doxycycline. Microbiological analysis comprised the detection of Tannerella forsythia (Tf), Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and Prevotella intermedia (Pi) by polymerase chain reaction method.

resultsSixty-eight (33 CG and 35 TG) subjects completed the study. Greater reduction in the population of Tf, Pg, and Pi were observed in TG compared with CG in the first month after the administration of systemic doxycycline. The TG showed a significant improvement in gingival index scores compared with the CG (p<0.05) by the end of the first and 6 months after the administration of doxycycline.

conclusionAdjunct systemic doxycycline can be associated with a reduction of Tf, Pg, and Pi in the first month after the administration of doxycycline with an improvement in the GI.

Indexed as

AdultAggregatibacter actinomycetemcomitansAnti-Bacterial AgentsBacteroidaceae InfectionsBacteroidetesChronic PeriodontitisDental ScalingDiabetes Mellitus, Type 2DNA, BacterialDoxycyclineFemaleHumansMaleMiddle AgedPasteurellaceae InfectionsPeriodontal IndexAnti-Bacterial AgentsDNA, BacterialDoxycycline

Identifiers

PMID25316464
PMCPMC4362117
OpenAlexW1612757756

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.