Evidence map›Paper›PMID 25315782›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2015

Early pragmatic language difficulties in siblings of children with autism: implications for DSM-5 social communication disorder?

Meghan Miller, Gregory S Young, Ted Hutman, Scott Johnson, A J Schwichtenberg, Sally Ozonoff

Abstract read
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Narrative Ability in Autism and First-Degree Relatives.Journal of autism and developmental disorders · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Utility of the Language Use Inventory in Young Children at Elevated Likelihood of Autism.Journal of speech, language, and hearing research : JSLHR · 2024
    Article
  10. Review
  11. Prevalence and functional impact of social (pragmatic) communication disorders.Journal of child psychology and psychiatry, and allied disciplines · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Genetic Advances in Autism.Journal of autism and developmental disorders · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Meghan MillerMIND Institute, University of California, Davis, Sacramento, CA, USA.
Gregory S YoungMIND Institute, University of California, Davis, Sacramento, CA, USA.
Ted HutmanDepartment of Psychiatry, University of California, Los Angeles, CA, USA.
Scott JohnsonDepartment of Psychiatry, University of California, Los Angeles, CA, USA.
A J SchwichtenbergDepartment of Human Development and Family Studies, Psychological Sciences and Speech Language and Hearing Sciences, Purdue University, West Lafayette, IN, USA.
Sally OzonoffMIND Institute, University of California, Davis, Sacramento, CA, USA.
University of California, Davis · USUniversity of California, Los Angeles · USPurdue University West Lafayette · US

Funding

Understanding Repetitive Behavior in AutismP50HD055784 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOOKHEIMER, SUSAN Y · 2007 to 2021
$32.0M
Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SIMON, TONY J · 2013 to 2019
$8.5M
Social &Language Deficits in Autism-Biology &TreamentU54MH068172 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SIGMAN, MARIAN D · 2003 to 2007
$8.2M
Infants at Risk of Autism: A Longitudinal StudyR01MH068398 · NIMH · UNIVERSITY OF CALIFORNIA DAVIS · PI OZONOFF, SALLY · 2003 to 2013
$6.1M
An investigation of transdiagnostic mechanisms underlying ASD and ADHD traits among infants at riskR01MH121416 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MILLER, MEGHAN RHYS · 2020 to 2024
$3.9M
Self-Regulation and Sleep in Children At Risk for Autism Spectrum DisordersR00MH092431 · NIMH · PURDUE UNIVERSITY · PI SCHWICHTENBERG, AMY J · 2013 to 2015
$734k
Self-Regulation and Sleep in Children At Risk for Autism Spectrum DisordersK99MH092431 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SCHWICHTENBERG, AMY J · 2011 to 2012
$178k
NICHD NIH HHS P50 HD055784NICHD NIH HHS P50 HD055784NICHD NIH HHS U54 HD079125NIMH NIH HHS K99 MH092431NIMH NIH HHS R00 MH092431NIMH NIH HHS R01 MH068398NIMH NIH HHS R01 MH121416NIMH NIH HHS U54 MH068172PHS HHS NIMH R01 MH068398
6 · The paper itself

Abstract

backgroundWe evaluated early pragmatic language skills in preschool-age siblings of children with autism spectrum disorder (ASD), and examined correspondence between pragmatic language impairments and general language difficulties, autism symptomatology, and clinical outcomes.

methodsParticipants were younger siblings of children with ASD (high-risk, n = 188) or typical development (low-risk, n = 119) who were part of a prospective study of infants at risk for ASD; siblings without ASD outcomes were included in analyses. Pragmatic language skills were measured via the Language Use Inventory (LUI).

resultsAt 36 months, the high-risk group had significantly lower parent-rated pragmatic language scores than the low-risk group. When defining pragmatic language impairment (PLI) as scores below the 10(th) percentile on the LUI, 35% of the high-risk group was identified with PLI versus 10% of the low-risk group. Children with PLI had higher rates of general language impairment (16%), defined as scores below the 10(th) percentile on the Receptive or Expressive Language subscales of the Mullen Scales of Early Learning, relative to those without PLI (3%), but most did not evidence general language impairments. Children with PLI had significantly higher ADOS scores than those without PLI and had higher rates of clinician-rated atypical clinical best estimate outcomes (49%) relative to those without PLI (15%).

conclusionsPragmatic language problems are present in some siblings of children with ASD as early as 36 months of age. As the new DSM-5 diagnosis of Social (Pragmatic) Communication Disorder (SCD) is thought to occur more frequently in family members of individuals with ASD, it is possible that some of these siblings will meet criteria for SCD as they get older. Close monitoring of early pragmatic language development in young children at familial risk for ASD is warranted.

Indexed as

Attention Deficit Disorder with HyperactivityAutism Spectrum DisorderChild, PreschoolDevelopmental DisabilitiesFemaleHumansInfantLanguage Development DisordersLongitudinal StudiesMalePhenotypeProspective StudiesRisk AssessmentSiblingsSocial Communication DisorderSocial Skillsautism spectrum disorderhigh-riskPragmatic languagesiblingssocial communicationsocial (pragmatic) communication disorder

Identifiers

PMID25315782
PMCPMC4398575
OpenAlexW2167512755

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.