ArticlePlant physiology2014
Nitric oxide plays a role in stem cell niche homeostasis through its interaction with auxin.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 111 citations in OpenAlex.
- Nitric oxide interacts with brassinosteroid signalling to regulate plant growth and development in an organ-specific manner.Journal of experimental botany · 2026Article
- Stem cell regulation: conserved pluripotency, transcriptional, and metabolic networks in animals and plants.Frontiers in cell and developmental biology · 2026Review
- The Hidden Architects: Nitric Oxide and Redox Dynamics in Plant Stem Cell Homeostasis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Species-specific modulation of nitro-oxidative stress and root growth in monocots by silica nanoparticle pretreatment under copper oxide nanoparticle stress.BMC plant biology · 2025Article
- Roles of the ArabidopsisInternational journal of molecular sciences · 2024Article
- Reversible S-nitrosylation of bZIP67 by peroxiredoxin IIE activity and nitro-fatty acids regulates the plant lipid profile.Cell reports · 2024Article
- Nitric oxide controls shoot meristem activity via regulation of DNA methylation.Nature communications · 2023Article
- Fine-tuned nitric oxide and hormone interface in plant root development and regeneration.Journal of experimental botany · 2023Review
- Preserving root stem cell functionality under low oxygen stress: the role of nitric oxide and phytoglobins.Planta · 2023Review
- RNA-Seq Transcriptome Analysis and Evolution ofInternational journal of molecular sciences · 2023Article
- HPlant, cell & environment · 2023Review
- The ROP2 GTPase Participates in Nitric Oxide (NO)-Induced Root Shortening in Arabidopsis.Plants (Basel, Switzerland) · 2023Article
- Elucidating connections between the strigolactone biosynthesis pathway, flavonoid production and root system architecture in Arabidopsis thaliana.Physiologia plantarum · 2022Article
- S-Nitrosoglutathione Reductase Contributes to Thermotolerance by Modulating High Temperature-Induced Apoplastic HFrontiers in plant science · 2022Article
- Redox feedback regulation of ANAC089 signaling alters seed germination and stress response.Cell reports · 2021Article
- The AtCRK5 Protein Kinase Is Required to Maintain the ROS NO Balance Affecting the PIN2-Mediated Root Gravitropic Response in Arabidopsis.International journal of molecular sciences · 2021Article
- Nitric oxide function during oxygen deprivation in physiological and stress processes.Journal of experimental botany · 2021Review
- The Role of Nitric Oxide-InducedFrontiers in plant science · 2021Article
- Nitric Oxide Alters the Pattern of Auxin Maxima and PIN-FORMED1 During Shoot Development.Frontiers in plant science · 2021Article
- Canavanine Increases the Content of Phenolic Compounds in Tomato (Plants (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is a unique reactive nitrogen molecule with an array of signaling functions that modulates plant developmental processes and stress responses. To explore the mechanisms by which NO modulates root development, we used a pharmacological approach and NO-deficient mutants to unravel the role of NO in establishing auxin distribution patterns necessary for stem cell niche homeostasis. Using the NO synthase inhibitor and Arabidopsis (Arabidopsis thaliana) NO biosynthesis mutants (nitric oxide-associated1 [noa1], nitrate reductase1 [nia1] and nia2, and nia1 nia2 noa1), we show that depletion of NO in noa1 reduces primary root elongation and increases flavonol accumulation consistent with elevated reactive oxygen species levels. The elevated flavonols are required for the growth effect, because the transparent testa4 mutation reverses the noa1 mutant root elongation phenotype. In addition, noa1 and nia1 nia2 noa1 NO-deficient mutant roots display small root meristems with abnormal divisions. Concomitantly, auxin biosynthesis, transport, and signaling are perturbed. We further show that NO accumulates in cortex/endodermis stem cells and their precursor cells. In endodermal and cortical cells, the noa1 mutant acts synergistically to the effect of the wuschel-related homeobox5 mutation on the proximal meristem, suggesting that NO could play an important role in regulating stem cell decisions, which has been reported in animals.
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