ArticleBiomechanics and modeling in mechanobiology2015
Estimating passive mechanical properties in a myocardial infarction using MRI and finite element simulations.
Article in Biomechanics and modeling in mechanobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
- Multiscale fiber remodeling in the infarcted left ventricle using a stress-based reorientation law.Acta biomaterialia · 2024Article
- Simulated Effects of Acute Left Ventricular Myocardial Infarction on Mitral Regurgitation in an Ovine Model.Journal of biomechanical engineering · 2024Article
- Advancing clinical translation of cardiac biomechanics models: a comprehensive review, applications and future pathways.Frontiers in physics · 2023Article
- Validating MRI-Derived Myocardial Stiffness Estimates Using In Vitro Synthetic Heart Models.Annals of biomedical engineering · 2023Article
- Bayesian optimisation for efficient parameter inference in a cardiac mechanics model of the left ventricle.International journal for numerical methods in biomedical engineering · 2022Article
- Multiscale Contrasts Between the Right and Left Ventricle Biomechanics in Healthy Adult Sheep and Translational Implications.Frontiers in bioengineering and biotechnology · 2022Article
- Passive myocardial mechanical properties: meaning, measurement, models.Biophysical reviews · 2021Review
- Personalized intervention cardiology with transcatheter aortic valve replacement made possible with a non-invasive monitoring and diagnostic framework.Scientific reports · 2021Article
- Application of feed forward and recurrent neural networks in simulation of left ventricular mechanics.Scientific reports · 2020Article
- Biomechanics of infarcted left ventricle: a review of modelling.Biomedical engineering letters · 2020Review
- Intra-myocardial alginate hydrogel injection acts as a left ventricular mid-wall constraint in swine.Acta biomaterialia · 2020Article
- Current Understanding of the Biomechanics of Ventricular Tissues in Heart Failure.Bioengineering (Basel, Switzerland) · 2019Review
- Effects of hydrogel injection on borderzone contractility post-myocardial infarction.Biomechanics and modeling in mechanobiology · 2018Article
- In vivo estimation of elastic heterogeneity in an infarcted human heart.Biomechanics and modeling in mechanobiology · 2018Article
- Structural modelling of the cardiovascular system.Biomechanics and modeling in mechanobiology · 2018Review
- In vivo estimation of passive biomechanical properties of human myocardium.Medical & biological engineering & computing · 2018Article
- Gaussian Process Regressions for Inverse Problems and Parameter Searches in Models of Ventricular Mechanics.Frontiers in physiology · 2018Article
- Construction and Validation of Subject-Specific Biventricular Finite-Element Models of Healthy and Failing Swine Hearts From High-Resolution DT-MRI.Frontiers in physiology · 2018Article
- A Novel Nonlinear Parameter Estimation Method of Soft Tissues.Genomics, proteomics & bioinformatics · 2017Article
- Improved identifiability of myocardial material parameters by an energy-based cost function.Biomechanics and modeling in mechanobiology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Myocardial infarction (MI) triggers a series of maladaptive events that lead to structural and functional changes in the left ventricle. It is crucial to better understand the progression of adverse remodeling, in order to develop effective treatment. In addition, being able to assess changes in vivo would be a powerful tool in the clinic. The goal of the current study is to quantify the in vivo material properties of infarcted and remote myocardium 1 week after MI, as well as the orientation of collagen fibers in the infarct. This will be accomplished by using a combination of magnetic resonance imaging (MRI), catheterization, finite element modeling, and numerical optimization to analyze a porcine model ([Formula: see text]) of posterolateral myocardial infarction. Specifically, properties will be determined by minimizing the difference between in vivo strains and volume calculated from MRI and finite element model predicted strains and volume. The results indicate that the infarct region is stiffer than the remote region and that the infarct collagen fibers become more circumferentially oriented 1 week post-MI. These findings are consistent with previous studies, which employed ex vivo techniques. The proposed methodology will ultimately provide a means of predicting remote and infarct mechanical properties in vivo at any time point post-MI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.