SynthesisAmerican journal of hypertension2015
Prognostic significance of the morning blood pressure surge in clinical practice: a systematic review.
Synthesis in American journal of hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- 2025 Thai Hypertension Society Guidance for Ambulatory Blood Pressure Monitoring in Adults.Journal of clinical hypertension (Greenwich, Conn.) · 2025Guideline
- Chronotherapy for morning blood pressure surge in hypertensive patients: a systematic review and meta-analysis.BMC cardiovascular disorders · 2021Pooled it
- Influence of acute dietary nitrate supplementation timing on nitrate metabolism, central and peripheral blood pressure and exercise tolerance in young men.European journal of applied physiology · 2024Trial
- CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial.Cardiovascular diabetology · 2016Trial
- Blood Pressure Variability (BPV): What Clinicians Need to Know a 2025 Expert Consensus Report Endorsed by the Egyptian Society of Cardiology.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Article
- Blood Pressure Regulation and Hypertension in Obstructive Sleep Apnea Syndrome: A Historical Perspective.Internal medicine (Tokyo, Japan) · 2024Review
- Ambulatory blood pressure monitoring profiles in Asia.Journal of clinical hypertension (Greenwich, Conn.) · 2024Review
- Time-variant associations of ambulatory pulse rate with short-term neurologic functional outcomes following acute ischemic stroke.Journal of human hypertension · 2023Article
- Different Factors Associated with Morning Blood Pressure Surge in Antihypertensive-Naïve Dipper and Non-Dipper Subjects.Journal of clinical medicine · 2023Article
- Association between Morning Surge and Left Ventricular Hypertrophy in Obese Hypertensive Patients.Arquivos brasileiros de cardiologia · 2023Article
- Correlation of blood pressure levels at different time periods throughout the day with total CSVD burden and MRI imaging markers.Frontiers in neurology · 2023Article
- 2022 Guidelines of the Taiwan Society of Cardiology and the Taiwan Hypertension Society for the Management of Hypertension.Acta Cardiologica Sinica · 2022Article
- Association of Morning Surge and Postexercise Heart Rate and Blood Pressure Recovery.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022Article
- Guidance on ambulatory blood pressure monitoring: A statement from the HOPE Asia Network.Journal of clinical hypertension (Greenwich, Conn.) · 2021Review
- Morning blood pressure surge is associated with autonomic neuropathy and peripheral vascular disease in patients with diabetes.Journal of human hypertension · 2020Article
- Morning Blood Pressure Surge and Cardiovascular Disease Events and All-Cause Mortality in Blacks: The Jackson Heart Study.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Factors related to time of stroke onset versus time of hospital arrival: A SITS registry-based study in an Egyptian stroke center.PloS one · 2020Article
- Ethnic disparities in the morning surge: Which utility for typifying the hypertensive patient?Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Expert panel consensus recommendations for ambulatory blood pressure monitoring in Asia: The HOPE Asia Network.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- Prognostic value of morning surge of blood pressure in middle-aged treated hypertensive patients.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundAn exaggerated morning blood pressure surge (MBPS) may be associated with stroke and other cardiovascular events, but the threshold at which an MBPS becomes pathological is unclear. This study aimed to systematically review the existing literature and establish the most appropriate definition of pathological MBPS.
methodsA MEDLINE search strategy was adapted for a range of literature databases to identify all prospective studies relating an exaggerated MBPS to cardiovascular endpoints. Hazard ratios (HRs) were extracted and synthesized using random-effects meta-analysis.
resultsThe search strategy identified 2,964 unique articles, of which 17 were eligible for the study. Seven different definitions of MBPS were identified; the most common was a prewaking surge (mean blood pressure for 2 hours after wake-up minus mean blood pressure for 2 hours before wake-up; n = 6 studies). Summary meta-analysis gave no clear evidence that prewaking MBPS (defined by a predetermined threshold: >25-55 mm Hg) was associated with all cardiovascular events (n = 2 studies; HR = 0.94, 95% confidence interval (CI) = 0.39-2.28) or stroke (n = 2 studies; HR = 1.26, 95% CI = 0.92-1.71). However, using a continuous scale, which has more power to detect an association, there was evidence that a 10 mm Hg increase in MBPS was related to an increased risk of stroke (n = 3 studies; HR = 1.11, 95% CI = 1.03-1.20).
conclusionsThese findings suggest that when measured and analyzed as a continuous variable, increasing levels of MBPS may be associated with increased risk of stroke. Large, protocol-driven individual patient data analyses are needed to accurately define this relationship further.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.