ArticleBMC complementary and alternative medicine2014
Central-stimulating and analgesic activity of the ethanolic extract of Alternanthera sessilis in mice.
Article in BMC complementary and alternative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Isolation of 3β-Hydroxylupenal From Ceriops decandra Leaves and Evaluation of In Vivo Analgesic and Anti-Inflammatory Effects Supported by Molecular Docking.BioMed research international · 2026Article
- Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review.Chemistry & biodiversity · 2025Review
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- Phyto-fabricated ZnO nanoparticles for anticancer, photo-antimicrobial effect on carbapenem-resistant/sensitive Pseudomonas aeruginosa and removal of tetracycline.Bioprocess and biosystems engineering · 2024Article
- A Review on Dry Eye Disease Treatment: Recent Progress, Diagnostics, and Future Perspectives.Pharmaceutics · 2023Review
- Protective Effects ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- The GenusFrontiers in pharmacology · 2022Review
- Cartilage protective and anti-analgesic effects of ALM16 on monosodium iodoacetate induced osteoarthritis in rats.BMC complementary and alternative medicine · 2019Article
- Analgesic Activity, Chemical Profiling and Computational Study onFrontiers in pharmacology · 2018Article
- Anti-Inflammatory and Antioxidant Activity of Acalypha hispida Leaf and Analysis of its Major Bioactive Polyphenols by HPLC.Advanced pharmaceutical bulletin · 2016Article
- Comparative study of neuropharmacological, analgesic properties and phenolic profile of Ajwah, Safawy and Sukkari cultivars of date palm (Oriental pharmacy and experimental medicine · 2016Article
- Studies on phytochemical, antioxidant, anti-inflammatory and analgesic activities of Euphorbia dracunculoides.BMC complementary and alternative medicine · 2015Article
- Alpha-glucosidase Inhibitory and Antioxidant Potential of Antidiabetic HerbPharmacognosy magazineArticle
- Pharmacological evaluation of Mallotus philippinensis (Lam.) Muell.-Arg. fruit hair extract for anti-inflammatory, analgesic and hypnotic activity.Journal of intercultural ethnopharmacologyArticle
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Authors and funding
11 authors.
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Abstract
backgroundAlternanthera sessilis is a popular vegetable and used in traditional medicinal practice of Bangladesh and other parts of Asia to relive tiredness, laziness, and sleeps as well as pain and inflammation. However, no report was found on the neuropharmacological and analgesic activity of this plant to-date. Present study was undertaken to evaluate the neuropharmacological and analgesic activity of the ethanol extract of A. sessilis whole plant (ETAS) in mice models.
methodsCentral stimulating activity was investigated by pentobarbitone induced sleeping time, open field, and hole cross tests. Analgesic activity was evaluated by acetic acid induced writhing and hot-plate methods. The tests were performed at 250 and 500 mg/kg body weight dose levels.
resultsIn sleeping time test, ETAS significantly (p < 0.001) increased the onset of sleep, and decreased the duration of sleep. In open field and hole cross tests, ETAS significantly (p < 0.001) increased the movements of mice which persisted throughout the study period. In writhing test, ETAS showed, significant (p < 0.001) inhibition of writhing reflex. In hot plate test, ETAS significantly (p < 0.001) raised the pain threshold. In HPLC analysis for polyphenols, (+)-catechin, rutin, ellagic acid, and quercetin were detected in ETAS (117.72, 490.74, 3007.26, and 13.85 mg/100 g of dry extract, respectively).
conclusionPresent study supported the traditional uses of A. sessilis and indicated that the plant can be a potential source of bioactive molecules.
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