Evidence map›Paper›PMID 25315381›Full record

ArticleArchives of gynecology and obstetrics2015

Surgical and systemic management of endometrial cancer: an international survey.

Christina Fotopoulou, Robert Kraetschell, Sean Dowdy, Keiichi Fujiwara, Nobuo Yaegashi, Domenica Larusso, Antonio Casado, Sven Mahner, Thomas J Herzog, Sean Kehoe and 5 more

Abstract read
In one paragraph

Article in Archives of gynecology and obstetrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
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  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 14 institutions in 8 countries.

Christina FotopoulouFrauenklinik, Universitätsklinik Charite, Campus Virchow, Berlin, Germany, chfotopoulou@gmail.com.
Robert Kraetschell
Sean Dowdy
Keiichi Fujiwara
Nobuo Yaegashi
Domenica Larusso
Antonio Casado
Sven Mahner
Thomas J Herzog
Sean Kehoe
Ignace Vergote
David Scott Miller
Christian Marth
Shingo Fujii
Jalid Sehouli
Charité - Universitätsmedizin Berlin · DEColumbia University Irving Medical Center · USFondazione IRCCS Istituto Nazionale dei Tumori · ITImperial College London · GBKitano Hospital · JPKU Leuven · BEMayo Clinic · USMedical University of Vienna · ATSaitama Medical University · JPThe University of Texas Southwestern Medical Center · USTohoku University · JPUniversidad San Carlos · PYUniversität Hamburg · DEUniversity of Birmingham · GB

Funding

UT Southwestern NCI National Clinical Trials Network Lead Academic Site - U10U10CA180870 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI GERBER, DAVID ERIC · 2014 to 2018
$3.4M
NCI NIH HHS U10 CA180870
6 · The paper itself

Abstract

purposeTo ascertain the spectrum of clinical management of endometrial carcinoma (EC) the largest international survey was conducted to evaluate and identify differences worldwide.

methodsAfter validation of a 15-item questionnaire regarding surgical and adjuvant treatment of EC in Germany, an English-adapted questionnaire was put online and posted to all the major gynecological cancer Societies worldwide for further distribution commencing in 2010 and continued for 26 months.

resultsA total of 618 Institutions around the world participated: Central Europe (CE), Southern Europe (SE), Northern Europe (NE), Asia and USA/Canada/UK. Both a therapeutic and staging value was attributed to systematic pelvic and paraaortic lymph node dissection (LND) in CE (74.6%) and in Asia (67.2%), as opposed to USA/UK where LND was mainly for staging purposes (53.5%; p < 0.001). LND was performed up to the renal veins in CE in 86.8%, in Asia in 80.8%, in USA/UK in 51.2% and in SE in 45.1% (p < 0.001) of cases. In advanced disease, centers from Asia were treated most with adjuvant chemotherapy alone (93.6%), as opposed to centers in SE, CE and UK/USA that employed combination chemo-radiotherapy in 90.9% (p < 0.001) of cases. Paclitaxel/carboplatin was mostly used followed by doxorubicin/cisplatin (75 vs. 23.3%; p < 0.001). In total, 94% of all participants supported the concept of treating EC patients within appropriate clinical trials.

conclusionsThere is broad range in both the surgical and adjuvant treatment of EC across different countries. Large-scale multicenter prospective trials are warranted to establish consistent, evidence-based guidelines to optimize treatment worldwide.

Indexed as

Guideline AdherencePractice Patterns, Physicians'Surveys and QuestionnairesAdjuvants, ImmunologicAgedChemotherapy, AdjuvantDiagnostic Techniques, Obstetrical and GynecologicalDrug Therapy, CombinationEndometrial NeoplasmsEthnicityFemaleGynecologic Surgical ProceduresHealth SurveysHumansLymph Node ExcisionProfessional PracticeAdjuvants, Immunologic

Identifiers

PMID25315381
PMCPMC5814301
OpenAlexW1991208460

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.