ArticleGenome biology2014
Genome of the house fly, Musca domestica L., a global vector of diseases with adaptations to a septic environment.
Article in Genome biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 1 of them a synthesis that pooled it.
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Who cites it
125 citing papers in PubMed, 1 synthesis or guideline pooled it, 305 citations in OpenAlex.
- A systematic review of human pathogens carried by the housefly (Musca domestica L.).BMC public health · 2018Pooled it
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- Functional Annotation and Comparative Analysis of Cytochrome P450 Protein Family Genes in Nine Chironomidae Species.Biology · 2025Article
- Effects of Indoxacarb on life history traits and population performance of the house fly, Musca domestica.Scientific reports · 2025Article
- Seasonal variation effect on different Physalis peruviana L. (Solanaceae) waste extracts and investigation of their efficacy against Culex pipiens and Musca domestica.Scientific reports · 2025Article
- Mortality of Musca domestica (Diptera: Muscidae) in response to exposure to a fungal entomopathogen in combination with eicosanoid biosynthesis inhibitors.Journal of insect science (Online) · 2025Article
- Chromosome-level genome assembly of the synanthropic fly Chrysomya megacephala: insights into oviposition location.BMC genomics · 2025Article
- Study of the effect of dryness and storage on Ceratonia siliqua L. stem extracts and evaluation of their insecticidal activity.Scientific reports · 2025Article
- A deep insight into the sialome of the house fly, Musca domestica, infected with the salivary gland hypertrophy virus (MdSGHV).Scientific reports · 2025Article
- Investigating the molecular mechanisms of deltamethrin resistance in Musca domestica populations from Saudi Arabia.Parasites & vectors · 2025Article
- The chromosome-level genome provides insights into the adaptive evolution of the visual system in Oratosquilla oratoria.BMC biology · 2025Article
- Behavioral response of house flies (Diptera: Muscidae) to 3 bittering agents.Journal of insect science (Online) · 2025Article
- Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes.PLoS pathogens · 2025Article
- The GPCR A35 regulates fecundity ofFrontiers in insect science · 2025Article
- Bioactive Potential of SomeInsects · 2024Article
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65 more citing papers are in PubMed but not listed here.
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Authors and funding
26 authors at 12 institutions in 4 countries.
Funding
Abstract
backgroundAdult house flies, Musca domestica L., are mechanical vectors of more than 100 devastating diseases that have severe consequences for human and animal health. House fly larvae play a vital role as decomposers of animal wastes, and thus live in intimate association with many animal pathogens.
resultsWe have sequenced and analyzed the genome of the house fly using DNA from female flies. The sequenced genome is 691 Mb. Compared with Drosophila melanogaster, the genome contains a rich resource of shared and novel protein coding genes, a significantly higher amount of repetitive elements, and substantial increases in copy number and diversity of both the recognition and effector components of the immune system, consistent with life in a pathogen-rich environment. There are 146 P450 genes, plus 11 pseudogenes, in M. domestica, representing a significant increase relative to D. melanogaster and suggesting the presence of enhanced detoxification in house flies. Relative to D. melanogaster, M. domestica has also evolved an expanded repertoire of chemoreceptors and odorant binding proteins, many associated with gustation.
conclusionsThis represents the first genome sequence of an insect that lives in intimate association with abundant animal pathogens. The house fly genome provides a rich resource for enabling work on innovative methods of insect control, for understanding the mechanisms of insecticide resistance, genetic adaptation to high pathogen loads, and for exploring the basic biology of this important pest. The genome of this species will also serve as a close out-group to Drosophila in comparative genomic studies.
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