ArticleMolecular microbiology2014
Mutually repressing repressor functions and multi-layered cellular heterogeneity regulate the bistable Salmonella fliC census.
Article in Molecular microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- SFB flagellin mediates cell adhesion, endocytosis and immune regulation in germ-free mice.Frontiers in immunology · 2025Article
- Analysis ofFrontiers in cellular and infection microbiology · 2023Review
- Identifying Bacterial Lineages in Salmonella by Flow Cytometry.EcoSal Plus · 2022Review
- Article
- Single Cell Analysis of Bistable Expression of Pathogenicity Island 1 and the Flagellar Regulon inMicroorganisms · 2021Article
- A Single Nucleotide Polymorphism inFrontiers in microbiology · 2021Article
- A mathematical model of flagellar gene regulation and construction in Salmonella enterica.PLoS computational biology · 2020Article
- Two Tandem Mechanisms Control Bimodal Expression of the Flagellar Genes in Salmonella enterica.Journal of bacteriology · 2020Article
- Flagellum-Mediated Mechanosensing and RflP Control Motility State of Pathogenic Escherichia coli.mBio · 2020Article
- Stochastic transcriptional pulses orchestrate flagellar biosynthesis inScience advances · 2020Article
- Functional Regulators of Bacterial Flagella.Annual review of microbiology · 2019Review
- Synergistic action of SPI-1 gene expression in Salmonella enterica serovar typhimurium through transcriptional crosstalk with the flagellar system.BMC microbiology · 2019Article
- Article
- Endogenously generated 2-aminoacrylate inhibits motility in Salmonella enterica.Scientific reports · 2017Article
- Salmonella STM1697 coordinates flagella biogenesis and virulence by restricting flagellar master protein FlhD4C2 from recruiting RNA polymerase.Nucleic acids research · 2017Article
- Involvement of Two-Component Signaling on Bacterial Motility and Biofilm Development.Journal of bacteriology · 2017Review
- Stochastic and Differential Activation of σFrontiers in microbiology · 2017Article
- Spontaneous mutations in the flhD operon generate motility heterogeneity in Escherichia coli biofilm.BMC microbiology · 2016Article
- Evasion and interference: intracellular pathogens modulate caspase-dependent inflammatory responses.Nature reviews. Microbiology · 2016Review
- Staying in Shape: the Impact of Cell Shape on Bacterial Survival in Diverse Environments.Microbiology and molecular biology reviews : MMBR · 2016Review
Corrections and comments
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2 authors.
Funding
Abstract
Bistable flagellar and virulence gene expression generates specialized Salmonella subpopulations with distinct functions. Repressing flagellar genes allows Salmonella to evade caspase-1 mediated host defenses and enhances systemic colonization. By definition, bistability arises when intermediate states of gene expression are rendered unstable by the underlying genetic circuitry. We demonstrate sustained bistable fliC expression in virulent Salmonella 14028 and document dynamic control of the distribution, or single-cell census, of flagellar gene expression by the mutually repressing repressors YdiV and FliZ. YdiV partitions cells into the fliC-OFF subpopulation, while FliZ partitions cells into the fliC-HIGH subpopulation at late time points during growth. Bistability of ΔfliZ populations and ydiV-independent FliZ control of flagellar gene expression provide evidence that the YdiV-FliZ mutually repressing repressor circuit is not required for bistability. Repression and activation by YdiV and FliZ (respectively) can shape the census of fliC expression independently, and bistability collapses into a predominantly intermediate population in the absence of both regulators. Metered expression of YdiV and FliZ reveals variable sensitivity to these regulators and defines conditions where expression of FliZ enhances fliC expression and where FliZ does not alter the fliC census. Thus, this evolved genetic circuitry coordinates multiple layers of regulatory heterogeneity into a binary response.
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