ArticleJournal of neurochemistry2015
Decreased carbon shunting from glucose toward oxidative metabolism in diet-induced ketotic rat brain.
Article in Journal of neurochemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Pharmacokinetic effects of a single dose nutritional ketone ester supplement on brain glucose and ketone metabolism in alcohol use disorder.Psychiatry research. Neuroimaging · 2026Trial
- NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Acute Supplementation of Beta-Hydroxybutyrate Increases Visual Cortical Excitability in Humans: A Combined Electro-EncephaloGraphy and Magnetic Resonance Spectroscopy Study.The European journal of neuroscience · 2025Article
- In vivo Detection and Correlation of Cerebral Ketone Bodies with Neurotransmitters in Streptozotocin-Induced Type 1 Diabetic Rats.Neurochemical research · 2025Article
- Ketogenic diet as a therapeutic approach in autism spectrum disorder: a narrative review.Metabolic brain disease · 2024Review
- Metabolic aspects of genetic ion channel epilepsies.Journal of neurochemistry · 2024Review
- Characterization of β-Hydroxybutyrate as a Cell Autonomous Fuel for Active Excitatory and Inhibitory Neurons: β-Hydroxybutyrate as a Fuel for Active Neurons.bioRxiv : the preprint server for biology · 2024Article
- Imaging brain glucose metabolism in vivo reveals propionate as a major anaplerotic substrate in pyruvate dehydrogenase deficiency.Cell metabolism · 2024Article
- Potential new roles for glycogen in epilepsy.Epilepsia · 2023Review
- Dietary medium chain triglycerides for management of epilepsy: New data from human, dog, and rodent studies.Epilepsia · 2021Review
- Murine deficiency of peroxisomal L-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis.Cellular and molecular life sciences : CMLS · 2021Article
- The Ketogenic Diet Revisited: Beyond Ketones.Frontiers in neurology · 2021Article
- A Ketogenic Diet and the Treatment of Autism Spectrum Disorder.Frontiers in pediatrics · 2021Review
- M-Channel Activation Contributes to the Anticonvulsant Action of the Ketone BodyThe Journal of pharmacology and experimental therapeutics · 2020Article
- Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency.Science translational medicine · 2019Article
- 2-Deoxyglucose and Beta-Hydroxybutyrate: Metabolic Agents for Seizure Control.Frontiers in cellular neuroscience · 2019Review
- Ketone Administration for Seizure Disorders: History and Rationale for Ketone Esters and Metabolic Alternatives.Frontiers in neuroscience · 2019Review
- Article
- Do ketone bodies mediate the anti-seizure effects of the ketogenic diet?Neuropharmacology · 2018Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The mechanistic link of ketosis to neuroprotection under certain pathological conditions continues to be explored. We investigated whether chronic ketosis induced by ketogenic diet results in the partitioning of ketone bodies toward oxidative metabolism in brain. We hypothesized that diet-induced ketosis results in increased shunting of ketone bodies toward citric acid cycle and amino acids with decreased carbon shunting from glucose. Rats were fed standard (STD) or ketogenic (KG) diets for 3.5 weeks and then infused with [U-(13) C]glucose or [U-(13) C]acetoacetate tracers. Concentrations and (13) C-labeling pattern of citric acid cycle intermediates and amino acids were analyzed from brain homogenates using stable isotopomer mass spectrometry analysis. The contribution of [U-(13) C]glucose to acetyl-CoA and amino acids decreased by ~ 30% in the KG group versus STD, whereas [U-(13) C]acetoacetate contributions were more than two-fold higher. The concentration of GABA remained constant across groups; however, the (13) C labeling of GABA was markedly increased in the KG group infused with [U-(13) C]acetoacetate compared to STD. This study reveals that there is a significant contribution of ketone bodies to oxidative metabolism and GABA in diet-induced ketosis. We propose that this represents a fundamental mechanism of neuroprotection under pathological conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.