ArticleMolecular ecology2014
Comparative functional genomics of adaptation to muscular disuse in hibernating mammals.
Article in Molecular ecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 66 citations in OpenAlex.
- Frozen and Scorched: Genomic Signatures of Adaptive Divergence and Hibernation in the Living FossilEcology and evolution · 2026Article
- Incorporation of microbially salvaged urea-nitrogen into anabolic amino acids during hibernation in arctic ground squirrels.Communications biology · 2026Article
- Incorporation of microbially salvaged urea-nitrogen into anabolic amino acids during hibernation in arctic ground squirrels.bioRxiv : the preprint server for biology · 2025Article
- Harnessing hibernation: Unlocking nature's secrets for advances in healthy aging, critical care, and space exploration.Annals of the New York Academy of Sciences · 2025Review
- Transcriptome Remodeling and Adaptive Preservation of Muscle Protein Content in Hibernating Black Bears.Ecology and evolution · 2025Article
- Skeletal muscle preservation in arctic ground squirrels during hibernation season.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2025Article
- Transcriptome remodeling and adaptive preservation of muscle protein content in hibernating black bears.bioRxiv : the preprint server for biology · 2025Article
- Microbial urea-nitrogen recycling in arctic ground squirrels: the effect of ambient temperature of hibernation.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Molecular regulation of reversible cardiac remodeling: lessons from species with extreme physiological adaptations.The Journal of experimental biology · 2024Review
- Effects of Hibernation on Colonic Epithelial Tissue and Gut Microbiota in Wild Chipmunks (Animals : an open access journal from MDPI · 2024Article
- Article
- Pre-hibernation diet alters skeletal muscle relaxation kinetics, but not force development in torpid arctic ground squirrels.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Cold resistance of mammalian hibernators ∼ a matter of ferroptosis?Frontiers in physiology · 2024Review
- Feeding during hibernation shifts gene expression toward active season levels in brown bears (Physiological genomics · 2023Article
- A multi-tissue gene expression dataset for hibernating brown bears.BMC genomic data · 2023Article
- Article
- Microbial gene expression during hibernation in arctic ground squirrels: greater differences across gut sections than in response to pre-hibernation dietary protein content.Frontiers in genetics · 2023Article
- Aestivation induces widespread transcriptional changes in the African lungfish.Frontiers in genetics · 2023Article
- Differential AMPK-mediated metabolic regulation observed in hibernation-style polymorphisms in Siberian chipmunks.Frontiers in physiology · 2023Article
- Regulation of protein and oxidative energy metabolism are down-regulated in the skeletal muscles of Asiatic black bears during hibernation.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Hibernation is an energy-saving adaptation that involves a profound suppression of physical activity that can continue for 6-8 months in highly seasonal environments. While immobility and disuse generate muscle loss in most mammalian species, in contrast, hibernating bears and ground squirrels demonstrate limited muscle atrophy over the prolonged periods of physical inactivity during winter, suggesting that hibernating mammals have adaptive mechanisms to prevent disuse muscle atrophy. To identify common transcriptional programmes that underlie molecular mechanisms preventing muscle loss, we conducted a large-scale gene expression screen in hind limb muscles comparing hibernating and summer-active black bears and arctic ground squirrels using custom 9600 probe cDNA microarrays. A molecular pathway analysis showed an elevated proportion of overexpressed genes involved in all stages of protein biosynthesis and ribosome biogenesis in muscle of both species during torpor of hibernation that suggests induction of translation at different hibernation states. The induction of protein biosynthesis probably contributes to attenuation of disuse muscle atrophy through the prolonged periods of immobility of hibernation. The lack of directional changes in genes of protein catabolic pathways does not support the importance of metabolic suppression for preserving muscle mass during winter. Coordinated reduction in multiple genes involved in oxidation-reduction and glucose metabolism detected in both species is consistent with metabolic suppression and lower energy demand in skeletal muscle during inactivity of hibernation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.