ArticleJournal of acquired immune deficiency syndromes (1999)2014
T-cell activation, both pre- and post-HAART levels, correlates with carotid artery stiffness over 6.5 years among HIV-infected women in the WIHS.
Article in Journal of acquired immune deficiency syndromes (1999), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- The effect of physical activity on cardiometabolic health and inflammation in treated HIV infection.Antiviral therapy · 2016Trial
- Angiogenic CD8 T cells from PWH induce Granzymes-dependent PAR1 activation promoting endothelial inflammation.bioRxiv : the preprint server for biology · 2025Article
- Central arterial stiffness in young adults with perinatal HIV exposure and infection.AIDS (London, England) · 2025Article
- Article
- Inflammation in HIV and Its Impact on Atherosclerotic Cardiovascular Disease.Circulation research · 2024Review
- Vascular dysfunction and body mass index in African adults with HIV.BMC cardiovascular disorders · 2023Article
- Immune correlates of cardiovascular co-morbidity in HIV infected participants from South India.BMC immunology · 2022Article
- Cardiovascular Implications of Immune Disorders in Women.Circulation research · 2022 · on this mapReview
- T-Cell Immune Dysregulation and Mortality in Women With Human Immunodeficiency Virus.The Journal of infectious diseases · 2022Article
- A Step Closer to the "Fourth 90": A Practical Narrative Review of Diagnosis and Management of Nutritional Issues of People Living with HIV.Diagnostics (Basel, Switzerland) · 2021Review
- Immune activation and arterial stiffness in lean adults with HIV on antiretroviral therapy.Southern African journal of HIV medicine · 2021Article
- Increased carotid artery wall stiffness and plaque prevalence in HIV infected patients measured with ultrasound elastography.European radiology · 2020Article
- Cytomegalovirus-specific CD8+ T-cell responses are associated with arterial blood pressure in people living with HIV.PloS one · 2020Article
- Monocyte and T Cell Immune Phenotypic Profiles Associated With Age Advancement Differ Between People With HIV, Lifestyle-Comparable Controls and Blood Donors.Frontiers in immunology · 2020Article
- Insomnia as an Independent Predictor of Incident Cardiovascular Disease in HIV: Data From the Veterans Aging Cohort Study.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Posttransplant Immune Activation: Innocent Bystander or Insidious Culprit of Posttransplant Accelerated Atherosclerosis.Cell transplantation · 2017Review
- HIV-1-Associated Atherosclerosis: Unraveling the Missing Link.Journal of the American College of Cardiology · 2017Review
- Association of T Cell and Macrophage Activation with Arterial Vascular Health in HIV.AIDS research and human retroviruses · 2017Article
- Article
- Role of T-Cell Dysfunction, Inflammation, and Coagulation in Microvascular Disease in HIV.Journal of the American Heart Association · 2016Article
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Authors and funding
12 authors at 8 institutions in 1 country.
Funding
Abstract
objectiveT-cell activation is a major pathway driving HIV disease progression. Little is known regarding the impact of T-cell activation on HIV-associated atherosclerosis and cardiovascular disease, a common comorbidity in HIV infection. We hypothesized that T-cell activation will predict vascular stiffness, a measure of subclinical atherosclerosis.
designLinear regression models evaluated the covariate-adjusted association of T-cell activation with vascular stiffness.
methodsCD38 and HLA-DR expression on CD4⁺ and CD8⁺ T cells was assessed by flow cytometry among 59 HIV-negative and 376 HIV-infected (185 hepatitis C coinfected) women in the Women's Interagency HIV Study. T-cell activation was defined by CD8⁺CD38⁺DR+ and CD4⁺CD3⁺8DR+. Multiple activation assessments over 6.5 years were averaged. In 140 women, T-cell activation was measured before and after highly active antiretroviral therapy (HAART) initiation. Carotid artery ultrasounds were completed a median of 6.5 years after last measurement of T-cell activation and carotid artery stiffness including distensibility and elasticity were calculated.
resultsPercentages of CD4⁺ and CD8⁺ T-cell activation were significantly higher in HIV- infected compared with HIV-negative women. Among HIV-negative women, T-cell activation was not associated with carotid artery stiffness. Among HIV-infected women, higher CD4⁺ T-cell activation levels significantly predicted increased arterial stiffness independent of CD4⁺ cell count and HIV RNA. The association was stronger among HIV/hepatitis C-coinfected women compared with HIV-monoinfected women; however, the difference was not statistically significant (P for interaction >0.05). Pre- and post-HAART levels of CD4⁺ T-cell activation significantly predicted carotid artery stiffness.
conclusionsPersistent T-cell activation, even after HAART initiation, can contribute to structural and/or functional vascular damage accelerating atherogenesis in HIV infection. These results need to be confirmed in a longitudinal prospective study.
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