Evidence map›Paper›PMID 25314251›Full record

Observational studyJournal of acquired immune deficiency syndromes (1999)2014

Management of fever in ambulatory HIV-infected adults in resource-limited settings: prospective observational evaluation of a new Mozambican guideline.

Paula E Brentlinger, Wilson P Silva, Manuel Buene, Luis Morais, Emilio Valverde, Sten H Vermund, Troy D Moon

Erratum issuedAbstract readEvaluation StudyObservational Study
In one paragraph

Observational study in Journal of acquired immune deficiency syndromes (1999), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

7 authors.

Paula E Brentlinger*Friends in Global Health, LLC, Maputo, Mozambique; †Vanderbilt Institute for Global Health, Nashville, TN; and ‡Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN.
Wilson P Silva
Manuel Buene
Luis Morais
Emilio Valverde
Sten H Vermund
Troy D Moon

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Vanderbilt Rural Mozambique Project: Proposal for PEPFAR-Supported Care and TreatU2GPS000631 · PS · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2012
$40.2M
NCATS NIH HHS UL1 TR000445NCHHSTP CDC HHS U2G PS000631PEPFAR U2GPS000631
6 · The paper itself

Abstract

A new Mozambican guideline for management of fever in HIV-infected adults requires malaria testing and systematic consideration of specific alternative diagnoses (eg, tuberculosis and bacterial infections) in addition to malaria. We conducted a prospective observational study of the guideline's performance. Of 258 HIV-infected subjects with axillary temperature ≥37.5° C or history of fever, 76.0% improved, 13.6% died or were hospitalized, and 10.5% were lost to follow-up. In multivariate analyses, factors associated with adverse outcomes were bacterial blood stream infection, syndromically diagnosed tuberculosis, lower CD4 T-lymphocyte count, no antiretroviral therapy, lower body mass index, lower hemoglobin, and nonprescription of antibiotics.

Indexed as

AdultAIDS-Related Opportunistic InfectionsAmbulatory CareAnti-Bacterial AgentsAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBacterial InfectionsCD4 Lymphocyte CountDisease ManagementFemaleFeverHIV InfectionsHumansMaleMultivariate AnalysisOutcome Assessment, Health CareAnti-Bacterial AgentsAnti-HIV Agents

Identifiers

PMID25314251
PMCPMC5844466

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.