ArticleJournal of acquired immune deficiency syndromes (1999)2014
Association of markers of hemostasis with death in HIV-infected women.
Elizabeth Kiefer, Donald R Hoover, Qiuhu Shi, Mark H Kuniholm, Michael Augenbraun, Mardge H Cohen, Elizabeth T Golub, Robert C Kaplan, Chenglong Liu, Marek Nowicki and 3 more
Article in Journal of acquired immune deficiency syndromes (1999), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literature
Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors at 12 institutions in 1 country.
Elizabeth Kiefer*John A. Burns School of Medicine, University of Hawaii, Honolulu, HI; †Institute for Health, Health Care Policy and Aging Research, Rutgers University, Piscataway, NJ; ‡New York Medical College, Valhalla, NY; §Albert Einstein College of Medicine, Bronx, NY; ‖State University at Downstate Medical Center, Brooklyn, NY; ¶Stroger Hospital and Rush University, Chicago, IL; #John Hopkins Bloomberg School of Public Health, Baltimore, MD; **Georgetown University, Washington, DC; ††Los Angeles County and University of Southern California Medical Center, Los Angeles, CA; ‡‡University of California, San Francisco, San Francisco, CA; §§University of Vermont, Burlington, VT; and ‖‖Montefiore Medical Center, Bronx, NY.
Donald R Hoover
Qiuhu Shi
Mark H Kuniholm
Michael Augenbraun
Mardge H Cohen
Elizabeth T Golub
Robert C Kaplan
Chenglong Liu
Marek Nowicki
Phyllis C Tien
Russell P Tracy
Kathryn Anastos
Albert Einstein College of Medicine · USGeorgetown University · USJohns Hopkins University · USLos Angeles Medical Center · USMontefiore Medical Center · USNew York Medical College · USRush University · USRutgers, The State University of New Jersey · USSUNY Downstate Health Sciences University · USUniversity of California, San Francisco · USUniversity of Hawaiʻi at Mānoa · USUniversity of Vermont · US
Funding
UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
WOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0M
WIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4M
Core-010UL1TR001073 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, SHAMOON, HARRY · 2013 to 2017
$21.3M
Inflammatory and Immune Mechanisms of Atherosclerosis in HIV-Infected WomenR01HL095140 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KAPLAN, ROBERT C · 2008 to 2012
$3.8M
CVD and inflammation across the lifespan in HIV infected adults and childrenR21HL120394 · NHLBI · UNIVERSITY OF WASHINGTON · PI DELANEY, JOSEPH AUSTIN, KAPLAN, ROBERT C · 2013 to 2014
: In HIV negatives, markers of hemostasis, including D-dimer, factor VIII, plasminogen activator inhibitor-1 antigen (PAI-1), and total protein S are associated with all-cause and cardiovascular disease mortality. In HIV positives, studies of D-dimer and factor VIII with death were limited to short follow-up; associations of PAI-1 and total protein S with death have not been examined. In 674 HIV-infected women from the Women's Interagency HIV Study, markers from the first visit after enrollment were exposures of interest in multivariate analyses of death (AIDS and non-AIDS) in separate models at 5 and 16 years. There were 87 AIDS and 44 non-AIDS deaths at 5 years, and 159 AIDS and 113 non-AIDS deaths at 16 years. An inverse association of total protein S quartiles with non-AIDS deaths was observed at 5 (P trend = 0.002) and 16 years (P trend = 0.02); there was no association with AIDS deaths. The third quartile of PAI-1 was associated with AIDS deaths at 5 [hazard ratio (HR) = 4.0; 95% confidence interval (CI): 1.9 to 8.4] and 16 years (HR = 3.4; 95% CI: 1.9 to 5.9); and with non-AIDS deaths at 5 years (HR = 4.8; 95% CI: 1.6 to 13.9). D-dimer and factor VIII were not associated with AIDS or non-AIDS death at 5 or 16 years. Lower total Protein S was a consistent marker of non-AIDS death. We found no association between D-dimer with AIDS or non-AIDS death, in contrast to previous studies showing increased short-term (<5 years) mortality, which may represent sex differences or population heterogeneity. Given longer survival on highly active antiretroviral therapy, further studies of these markers are needed to determine their prognostic value.
Indexed as
AdultBiomarkersFactor VIIIFemaleFibrin Fibrinogen Degradation ProductsHemostasisHIV InfectionsHumansMiddle AgedMultivariate AnalysisPlasminogen Activator Inhibitor 1Predictive Value of TestsProspective StudiesProtein SUnited StatesBiomarkersFactor VIIIFibrin Fibrinogen Degradation Productsfibrin fragment DPlasminogen Activator Inhibitor 1Protein S
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