Evidence map›Paper›PMID 25314032›Full record

ArticlePloS one2014

Pre-illness isoflavone consumption and disease risk of ulcerative colitis: a multicenter case-control study in Japan.

Satoko Ohfuji, Wakaba Fukushima, Kenji Watanabe, Satoshi Sasaki, Hirokazu Yamagami, Masakazu Nagahori, Mamoru Watanabe, Yoshio Hirota, Japanese Case-Control Study Group for Ulcerative Colitis

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Review
  7. Review
  8. Article
  9. Isoflavones and inflammatory bowel disease.World journal of clinical cases · 2020
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Satoko OhfujiDepartment of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan.
Wakaba FukushimaDepartment of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan.
Kenji WatanabeDepartment of Gastroenterology, Osaka City University Faculty of Medicine, Osaka, Japan.
Satoshi SasakiDepartment of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan.
Hirokazu YamagamiDepartment of Gastroenterology, Osaka City University Faculty of Medicine, Osaka, Japan.
Masakazu NagahoriDepartment of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.
Mamoru WatanabeDepartment of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.
Yoshio HirotaDepartment of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan; Clinical Epidemiology Research Center, Medical Co. LTA, Fukuoka, Japan.
Japanese Case-Control Study Group for Ulcerative Colitis
Osaka City University · JPTokyo Medical and Dental University · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPrevious studies have suggested that estrogens play a role in the development of ulcerative colitis (UC). Because isoflavones have a similar structure to 17β-estradiol, dietary consumption of isoflavones may have similar influences on the development of UC. We examined the association between pre-illness isoflavone consumption and the risk of UC. MATERIALS AND

methodsWe conducted a hospital-based case control study, and compared the dietary habits of 126 newly diagnosed UC cases with those of 170 age- and gender-matched hospital controls. Information on dietary factors was collected using a self-administered diet history questionnaire. To consider potential changes in dietary habits due to disease symptoms, the habits were assessed separately during the previous 1 month and at 1 year before the recruitment.

resultsIn the assessment of dietary habits during the previous 1 month, the highest tertile of isoflavone consumption revealed an increased odds ratio (OR) for UC (OR = 2.79; 95% confidence interval (CI), 1.39-5.59; Trend P = 0.004). A significant association was also observed for the dietary assessment at 1 year before, when most UC cases had not yet experienced their first disease symptoms (OR = 2.06; 95% CI, 1.05-4.04; Trend P = 0.04). Associations were more pronounced in females (OR in highest tertile of isoflavone consumption at 1 year before = 4.76; 95% CI, 1.30-17.5; Trend P = 0.02) but were obscured in males (corresponding OR = 1.21; 95% CI, 0.49-3.01; Trend P = 0.63).

conclusionsDietary isoflavone consumption may be associated with an increased risk of UC, particularly in females. Prospective cohort studies are warranted to confirm these findings.

Indexed as

DietIsoflavonesAdultAgedAge of OnsetCase-Control StudiesColitis, UlcerativeFemaleHumansJapanMaleMiddle AgedOdds RatioRisk FactorsYoung AdultIsoflavones

Identifiers

PMID25314032
PMCPMC4196952
OpenAlexW2043032477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.