ArticleAnxiety, stress, and coping2015
Effect of the 5-HTTLPR polymorphism on posttraumatic stress disorder, depression, anxiety, and quality of life among Iraq and Afghanistan veterans.
Article in Anxiety, stress, and coping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01123642 (Functional Outcomes in OEF/OIF Veterans With PTSD and Alcohol Misuse), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Functional Outcomes in OEF/OIF Veterans With PTSD and Alcohol Misuse
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Pharmacogenetics and Pharmacotherapy of Military Personnel Suffering from Post-traumatic Stress Disorder.Current neuropharmacology · 2017Pooled it
- Genome-wide association study of posttraumatic stress disorder in a cohort of Iraq-Afghanistan era veterans.Journal of affective disorders · 2015Pooled it
- A Re-evaluation of Candidate Gene Studies for Well-Being in Light of Genome-Wide Evidence.Journal of happiness studies · 2022Article
- Depression, temporomandibular disorders, and genetic polymorphisms in IL6 impact on oral health-related quality of life in patients requiring orthognathic surgery.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Genetic and Neuroimaging Approaches to Understanding Post-Traumatic Stress Disorder.International journal of molecular sciences · 2020Review
- Serotonin transporter-linked polymorphic region genotypes in relation to stress conditions among patients with papillary thyroid carcinoma.International journal of clinical and experimental pathology · 2019Article
- A genome-wide association study of suicide attempts and suicidal ideation in U.S. military veterans.Psychiatry research · 2018Article
- ADHD and nonsuicidal self-injury in male veterans with and without PTSD.Psychiatry research · 2017Article
- PTSD, alcohol dependence, and conduct problems: Distinct pathways via lability and disinhibition.Addictive behaviors · 2017Article
- Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder.Psychiatry research · 2015Article
- Peripheral Biomarker Candidates of Posttraumatic Stress Disorder.Experimental neurobiology · 2015Review
- A rodent model of traumatic stress induces lasting sleep and quantitative electroencephalographic disturbances.ACS chemical neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesPosttraumatic stress disorder (PTSD), depression, anxiety, and stress are significant problems among returning veterans and are associated with reduced quality of life.
designA correlational design was used to examine the impact of a polymorphism (5-HTTLPR) in the serotonin transporter promoter gene on post-deployment adjustment among returning veterans.
methodsA total of 186 returning Iraq and Afghanistan veterans were genotyped for the 5-HTTLPR polymorphism. Symptoms of PTSD, depression, general stress, and anxiety were assessed along with quality of life.
resultsAfter controlling for combat exposure, age, sex of the participant, and race, 5-HTTLPR had a significant multivariate effect on post-deployment adjustment, such that S' carriers reported more post-deployment adjustment problems and worse quality of life than veterans homozygous for the L' allele. This effect was larger when the analyses were restricted to veterans of European ancestry.
conclusionsOur findings suggest that veterans who carry the S' allele of the 5-HTTLPR polymorphism may be at increased risk for adjustment problems and reduced quality of life following deployments to war zones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.