ArticleDevelopmental cell2014
Su(H)-mediated repression positions gene boundaries along the dorsal-ventral axis of Drosophila embryos.
Article in Developmental cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Notch Signalling Plays a Role in Patterning the Ventral Mesoderm During Early Embryogenesis inInternational journal of molecular sciences · 2026Article
- The proximal enhancer of the snail gene mediates negative autoregulatory feedback in Drosophila melanogaster.Genetics · 2025Article
- Article
- Prediction and analysis of cis-regulatory elements in Dorsal and Ventral patterning genes of Tribolium castaneum and its comparison with Drosophila melanogaster.Molecular and cellular biochemistry · 2024Article
- Desensitisation of Notch signalling through dynamic adaptation in the nucleus.The EMBO journal · 2021Article
- Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor.PLoS genetics · 2021Article
- Dynamic patterning by morphogens illuminated by cis-regulatory studies.Development (Cambridge, England) · 2021Review
- Transcriptional Enhancers inGenetics · 2020Review
- Setting up for gastrulation: D. melanogaster.Current topics in developmental biology · 2020Review
- Coacting enhancers can have complementary functions within gene regulatory networks and promote canalization.PLoS genetics · 2019Article
- Distinct Roles of Broadly Expressed Repressors Support Dynamic Enhancer Action and Change in Time.Cell reports · 2019Article
- The Drosophila Pioneer Factor Zelda Modulates the Nuclear Microenvironment of a Dorsal Target Enhancer to Potentiate Transcriptional Output.Current biology : CB · 2019Article
- Article
- Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila.Nature communications · 2017Article
- Broadly expressed repressors integrate patterning across orthogonal axes in embryos.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Assessing regulatory information in developmental gene regulatory networks.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Drosophila poised enhancers are generated during tissue patterning with the help of repression.Genome research · 2017Article
- Stepwise Progression of Embryonic Patterning.Trends in genetics : TIG · 2016Review
- Article
- Neural Progenitors Adopt Specific Identities by Directly Repressing All Alternative Progenitor Transcriptional Programs.Developmental cell · 2016Article
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Authors and funding
4 authors.
Funding
Abstract
In Drosophila embryos, a nuclear gradient of the Dorsal (Dl) transcription factor directs differential gene expression along the dorsoventral (DV) axis, translating it into distinct domains that specify future mesodermal, neural, and ectodermal territories. However, the mechanisms used to differentially position gene expression boundaries along this axis are not fully understood. Here, using a combination of approaches, including mutant phenotype analyses and chromatin immunoprecipitation, we show that the transcription factor Suppressor of Hairless, Su(H), helps define dorsal boundaries for many genes expressed along the DV axis. Synthetic reporter constructs also provide molecular evidence that Su(H) binding sites support repression and act to counterbalance activation through Dl and the ubiquitous activator Zelda. Our study highlights a role for broadly expressed repressors, like Su(H), and organization of transcription factor binding sites within cis-regulatory modules as important elements controlling spatial domains of gene expression to facilitate flexible positioning of boundaries across the entire DV axis.
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