ArticleAngewandte Chemie (International ed. in English)2014
Synthesis of di-, tri-, and tetrasubstituted oxetanes by rhodium-catalyzed O-H insertion and C-C bond-forming cyclization.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Synthetic Approaches and Biological Significance of Four-membered Heterocyclic Compounds.Current topics in medicinal chemistry · 2026Review
- Oxetanes: formation, reactivity and total syntheses of natural products.Beilstein journal of organic chemistry · 2025Review
- Enantioselective Phase-Transfer-Catalyzed Synthesis of Spirocyclic Azetidine Oxindoles.Organic letters · 2024Article
- Oxetanes in Drug Discovery Campaigns.Journal of medicinal chemistry · 2023Review
- Visible Light Photoredox-Catalyzed Decarboxylative Alkylation of 3-Aryl-Oxetanes and Azetidines via Benzylic Tertiary Radicals and Implications of Benzylic Radical Stability.The Journal of organic chemistry · 2023Article
- Development of NovelJournal of medicinal chemistry · 2021Article
- Recent Advances in Enantioselective Desymmetrizations of Prochiral Oxetanes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Review
- Preparation and Uses of Chlorinated Glycerol Derivatives.Molecules (Basel, Switzerland) · 2020Review
- Thermal Stability and Explosive Hazard Assessment of Diazo Compounds and Diazo Transfer Reagents.Organic process research & development · 2020Review
- Lithium-Catalyzed Thiol Alkylation with Tertiary and Secondary Alcohols: Synthesis of 3-Sulfanyl-Oxetanes as Bioisosteres.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Structurally Divergent Lithium Catalyzed Friedel-Crafts Reactions on Oxetan-3-ols: Synthesis of 3,3-Diaryloxetanes and 2,3-Dihydrobenzofurans.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?Angewandte Chemie (International ed. in English) · 2016Review
- Irreversible endo-selective diels-alder reactions of substituted alkoxyfurans: a general synthesis of endo-cantharimides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2015Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Oxetanes offer exciting potential as structural motifs and intermediates in drug discovery and materials science. Here an efficient strategy for the synthesis of oxetane rings incorporating pendant functional groups is described. A wide variety of oxetane 2,2-dicarboxylates were accessed in high yields, including functionalized 3-/4-aryl- and alkyl-substituted oxetanes and fused oxetane bicycles. Enantioenriched alcohols provided enantioenriched oxetanes with complete retention of configuration. The oxetane products were further derivatized, while the ring was maintained intact, thus highlighting their potential as building blocks for medicinal chemistry.
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