ArticleTranslational psychiatry2014
Peripherally triggered and GSK-3β-driven brain inflammation differentially skew adult hippocampal neurogenesis, behavioral pattern separation and microglial activation in response to ibuprofen.
Article in Translational psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 67 citations in OpenAlex.
- Article
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- Neuronal Damage in Murine Experimental Cerebral Malaria, Implications for Neuronal Repair and Sequelae.Cells · 2025Article
- Endotoxemia-induced inflammation in the absence of obesity decreases anxiety-like and impulsive behavior without affecting learning and memory.bioRxiv : the preprint server for biology · 2025Article
- Hyperresponsiveness to inflammatory stimulation in human neuronal-like cells from patients with inflammation-associated depression.Frontiers in psychiatry · 2025Article
- Empagliflozin-activated AMPK elicits neuroprotective properties in reserpine-induced depression via regulating dynamics of hippocampal autophagy/inflammation and PKCζ-mediated neurogenesis.Psychopharmacology · 2024Article
- Investigating the Impact of Intracerebroventricular Streptozotocin on Female Rats with and without Ovaries: Implications for Alzheimer's Disease.Neurochemical research · 2024Article
- The impact of adult neurogenesis on affective functions: of mice and men.Molecular psychiatry · 2024Review
- GSK3-Driven Modulation of Inflammation and Tissue Integrity in the Animal Model.International journal of molecular sciences · 2024Review
- Azithromycin preserves adult hippocampal neurogenesis and behavior in a mouse model of sepsis.Brain, behavior, and immunity · 2024Article
- Glycogen Synthase Kinase-3β, NLRP3 Inflammasome, and Alzheimer's Disease.Current medical science · 2023Review
- GSK-3β orchestrates the inhibitory innervation of adult-born dentate granule cells in vivo.Cellular and molecular life sciences : CMLS · 2023Article
- Progression of Alzheimer's disease parallels unusual structural plasticity of human dentate granule cells.Acta neuropathologica communications · 2022Article
- Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies.Brain : a journal of neurology · 2022Article
- Pathophysiology of Depression: Stingless Bee Honey Promising as an Antidepressant.Molecules (Basel, Switzerland) · 2022Review
- GSK-3β Inhibition in Birds Affects Social Behavior and Increases Motor Activity.Frontiers in physiology · 2022Article
- The brain consequences of systemic inflammation were not fully alleviated by ibuprofen treatment in mice.Pharmacological reports : PR · 2021Article
- Neuronal insulin signaling and brain structure in nondemented older adults: the Atherosclerosis Risk in Communities Study.Neurobiology of aging · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both familial and sporadic forms of Alzheimer disease (AD) present memory impairments. It has been proposed that these impairments are related to inflammation in relevant brain areas such as the hippocampus. Whether peripherally triggered and neuron-driven brain inflammation produce similar and equally reversible alterations is a matter of discussion. Here we studied the effects of ibuprofen administration on a familial AD mouse model overexpressing GSK-3β that presents severe brain inflammation. We compared these effects with those observed in a peripherally triggered brain inflammation model based on chronic lipopolysaccharide (LPS) administration. Both proinflammatory stimuli produced equivalent reversible morphological alterations in granule neurons; however, GSK-3β had a much more prominent role in newborn neuron connectivity, causing alterations that were not reversed by ibuprofen. Although both insults triggered similar behavioral impairments, ibuprofen rescued this defect in LPS-treated mice but did not produce any improvement in GSK-3β-overexpressing animals. This observation could be attributable to the different microglial phenotype induced by ibuprofen treatment. These data may be clinically relevant for AD therapies, as GSK-3β appears to determine the efficacy of ibuprofen treatment.
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