Evidence map›Paper›PMID 25313210›Full record

ArticleAntimicrobial agents and chemotherapy2015

In vitro activity of wALADin benzimidazoles against different life cycle stages of Plasmodium parasites.

Christian S Lentz, Julia M Sattler, Martina Fendler, Simon Gottwalt, Victoria S Halls, Silke Strassel, Sandra Arriens, Jeffrey S Hannam, Sabine Specht, Michael Famulok and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Christian S LentzInstitute of Medical Microbiology, Immunology and Parasitology, University Hospital of Bonn, Bonn, Germany.
Julia M SattlerUniversity Hospital Heidelberg, Department for Infectious Diseases, Parasitology Unit, Heidelberg, Germany.
Martina FendlerInstitute of Medical Microbiology, Immunology and Parasitology, University Hospital of Bonn, Bonn, Germany.
Simon GottwaltUniversity Hospital Heidelberg, Department for Infectious Diseases, Parasitology Unit, Heidelberg, Germany.
Victoria S HallsLIMES Institute, Chemical Biology & Medicinal Chemistry Unit, Universität Bonn, Bonn, Germany.
Silke StrasselInstitute of Medical Microbiology, Immunology and Parasitology, University Hospital of Bonn, Bonn, Germany.
Sandra ArriensInstitute of Medical Microbiology, Immunology and Parasitology, University Hospital of Bonn, Bonn, Germany.
Jeffrey S HannamLIMES Institute, Chemical Biology & Medicinal Chemistry Unit, Universität Bonn, Bonn, Germany.
Sabine SpechtInstitute of Medical Microbiology, Immunology and Parasitology, University Hospital of Bonn, Bonn, Germany.
Michael FamulokLIMES Institute, Chemical Biology & Medicinal Chemistry Unit, Universität Bonn, Bonn, Germany.
Ann-Kristin MuellerUniversity Hospital Heidelberg, Department for Infectious Diseases, Parasitology Unit, Heidelberg, Germany.
Achim HoeraufInstitute of Medical Microbiology, Immunology and Parasitology, University Hospital of Bonn, Bonn, Germany.
Kenneth M PfarrInstitute of Medical Microbiology, Immunology and Parasitology, University Hospital of Bonn, Bonn, Germany pfarr@microbiology-bonn.de.
University Hospital Bonn · DEUniversity of Bonn · DEHeidelberg University · DEUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

wALADin1 benzimidazoles are specific inhibitors of δ-aminolevulinic acid dehydratase from Wolbachia endobacteria of filarial nematodes. We report that wALADin1 and two derivatives killed blood stage Plasmodium falciparum in vitro (50% inhibitory concentrations, 39, 7.7, and 12.8 μM, respectively). One of these derivatives inhibited gliding motility of Plasmodium berghei ANKA infectious sporozoites with nanomolar affinity and blocked invasion into hepatocytes but did not affect intrahepatocytic replication. Hence, wALADin1 benzimidazoles are tools to study gliding motility and potential antiplasmodial drug candidates.

Indexed as

AntimalarialsBenzimidazolesHumansInhibitory Concentration 50Plasmodium bergheiPlasmodium falciparumPorphobilinogen SynthaseThiophenesToxoplasmaAntimalarialsBenzimidazolesPorphobilinogen SynthaseThiopheneswALADin1 compound

Identifiers

PMID25313210
PMCPMC4291411
OpenAlexW2119002318

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.