Evidence map›Paper›PMID 25313209›Full record

ArticleAntimicrobial agents and chemotherapy2015

Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method.

A Espinel-Ingroff, A Chowdhary, G M Gonzalez, J Guinea, F Hagen, J F Meis, G R Thompson, J Turnidge

Abstract readMulticenter Study
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Optimizing antifungal dosing for invasiveFrontiers in pharmacology · 2025
    Article
  6. Exposure ofPathogens (Basel, Switzerland) · 2023
    Article
  7. Article
  8. New Perspectives on Antimicrobial Agents: Isavuconazole.Antimicrobial agents and chemotherapy · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Frontiers in microbiology · 2021
    Article
  16. In vitro activity of isavuconazole against clinically isolated yeasts from Chile.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A Espinel-IngroffVCU Medical Center, Richmond, Virginia, USA avingrof@vcu.edu.
A ChowdharyVallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
G M GonzalezUniversidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.
J GuineaHospital General Universitario Gregorio Marañón, School of Medicine-Universidad Complutense, Madrid, Spain.
F HagenDepartment of Medical Microbiology & Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
J F MeisDepartment of Medical Microbiology & Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-3253-6080
G R ThompsonUniversity of California Davis Medical Center, Davis, California, USA.
J TurnidgeUniversity of Adelaide, Adelaide, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidemiological cutoff values (ECVs) of isavuconazole are not available for Cryptococcus spp. The isavuconazole ECVs based on wild-type (WT) MIC distributions for 438 Cryptococcus neoformans nongenotyped isolates, 870 isolates of genotype VNI, and 406 Cryptococcus gattii isolates from six laboratories and different geographical areas were 0.06, 0.12, and 0.25 μg/ml, respectively. These ECVs may aid in detecting non-WT isolates with reduced susceptibilities to isavuconazole.

Indexed as

Antifungal AgentsCryptococcosisCryptococcus gattiiCryptococcus neoformansGenotypeHumansMicrobial Sensitivity TestsNitrilesPyridinesTriazolesAntifungal AgentsisavuconazoleNitrilesPyridinesTriazoles

Identifiers

PMID25313209
PMCPMC4291414

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.