ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015
The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis.Aging cell · 2025Pooled it
- Macronutrient mixtures and interactions in health and disease.Nature reviews. Endocrinology · 2026Review
- Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species.Frontiers in genetics · 2026Review
- Determining the metabolic effects of dietary fat, sugars and fat-sugar interaction using nutritional geometry in a dietary challenge study with male mice.Nature communications · 2023Article
- Chow diet in mouse aging studies: nothing regular about it.GeroScience · 2023Article
- Anti-Parkinson Effects ofMarine drugs · 2023Article
- The Ketogenic Diet: Is It an Answer for Sarcopenic Obesity?Nutrients · 2022Review
- Short-Term Ketogenic Diet Induces a Molecular Response That Is Distinct From Dietary Protein Restriction.Frontiers in nutrition · 2022Article
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- Article
- The role of lipid metabolism in aging, lifespan regulation, and age-related disease.Aging cell · 2019Review
- The Impact of Aging, Calorie Restriction and Dietary Fat on Autophagy Markers and Mitochondrial Ultrastructure and Dynamics in Mouse Skeletal Muscle.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Highlights from the 2019 International Congress on Frailty and Sarcopenia Research.The Journal of frailty & aging · 2019Article
- Energy restriction in renal protection.The British journal of nutrition · 2018Review
- Aging extension and modifications of lipid metabolism in the monogonont rotifer Brachionus koreanus under chronic caloric restriction.Scientific reports · 2018Article
- Caloric Restriction Study Design Limitations in Rodent and Nonhuman Primate Studies.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle.Ageing research reviews · 2017Review
- Does eating less make you live longer and better? An update on calorie restriction.Clinical interventions in aging · 2017Review
- Looking Beyond Structure: Membrane Phospholipids of Skeletal Muscle Mitochondria.Trends in endocrinology and metabolism: TEM · 2016Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
Calorie restriction (CR) without malnutrition extends life span in several animal models. It has been proposed that a decrease in the amount of polyunsaturated fatty acids (PUFAs), and especially n-3 fatty acids, in membrane phospholipids may contribute to life span extension with CR. Phospholipid PUFAs are sensitive to dietary fatty acid composition, and thus, the purpose of this study was to determine the influence of dietary lipids on life span in CR mice. C57BL/6J mice were assigned to four groups (a 5% CR control group and three 40% CR groups) and fed diets with soybean oil (high in n-6 PUFAs), fish oil (high in n-3 PUFAs), or lard (high in saturated and monounsaturated fatty acids) as the primary lipid source. Life span was increased (p < .05) in all CR groups compared to the Control mice. Life span was also increased (p < .05) in the CR lard mice compared to animals consuming either the CR fish or soybean oil diets. These results indicate that dietary lipid composition can influence life span in mice on CR, and suggest that a diet containing a low proportion of PUFAs and high proportion of monounsaturated and saturated fats may maximize life span in animals maintained on CR.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.