ArticleLung cancer (Amsterdam, Netherlands)2014
Are there imaging characteristics associated with lung adenocarcinomas harboring ALK rearrangements?
Article in Lung cancer (Amsterdam, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- CT Characteristics of Non-Small Cell Lung Cancer With Anaplastic Lymphoma Kinase Rearrangement: A Systematic Review and Meta-Analysis.AJR. American journal of roentgenology · 2019Pooled it
- Individualized nomogram for predicting ALK rearrangement status in lung adenocarcinoma patients.European radiology · 2021Trial
- Review
- Intratumoral and peritumoral CT radiomics in predicting anaplastic lymphoma kinase mutations and survival in patients with lung adenocarcinoma: a multicenter study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- From Images to Genes: Radiogenomics Based on Artificial Intelligence to Achieve Non-Invasive Precision Medicine in Cancer Patients.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Correlation analysis between EGFR gene mutation status, ALK positivity and demographic data, tumor biomarkers, radiological and pathological features in patients with lung adenocarcinoma.Frontiers in oncology · 2025Article
- Unusual presentation ofRespiratory medicine case reports · 2024Article
- Radiomics/Radiogenomics in Lung Cancer: Basic Principles and Initial Clinical Results.Cancers · 2022Review
- Predicting anaplastic lymphoma kinase rearrangement status in patients with non-small cell lung cancer using a machine learning algorithm that combines clinical features and CT images.Frontiers in oncology · 2022Article
- Value of CT features for predicting EGFR mutations and ALK positivity in patients with lung adenocarcinoma.Scientific reports · 2021Article
- Radiomics in immuno-oncology.Immuno-oncology technology · 2021Review
- Molecular biomarkers in early stage lung cancer.Translational lung cancer research · 2021Review
- Radiogenomics in Interventional Oncology.Current oncology reports · 2021Review
- Artificial intelligence and hybrid imaging: the best match for personalized medicine in oncology.European journal of hybrid imaging · 2020Review
- Application of CT radiomics features to predict the EGFR mutation status and therapeutic sensitivity to TKIs of advanced lung adenocarcinoma.Translational cancer research · 2020Article
- Differentiating synchronous double primary lung adenocarcinomas from intrapulmonary metastasis by CT features, EGFR mutations and ALK rearrangement status.Journal of thoracic disease · 2020Article
- Role of imaging biomarkers in mutation-driven non-small cell lung cancer.World journal of clinical oncology · 2020Review
- CT features associated with EGFR mutations and ALK positivity in patients with multiple primary lung adenocarcinomas.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020Article
- Imaging Features and Metastatic Patterns of AdvancedAJR. American journal of roentgenology · 2020Article
- Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
introduction5% of lung adenocarcinomas harbor rearrangements of the anaplastic lymphoma kinase (ALK) gene. This study compared computed tomography (CT) imaging features in patients with ALK rearrangements and those with EGFR mutations. MATERIAL/
methods30 patients with ALK rearrangements were studied. 97 patients with epidermal growth factor receptor (EGFR) mutations were used as controls. Features assessed included size and location of thoracic lymphadenopathy, and the size, contour, consistency and location of the primary tumor.
results127 lung adenocarcinomas were examined. 30 (24%) tumors harbored ALK rearrangements, 97 (76%) tumors harbored EGFR mutations. ALK tumors had larger thoracic lymphadenopathy than the control group (p=0.005). Both readers identified 17 (57%) patients in the ALK group with lymph nodes >1.5cm. Reader 1 identified 19 (20%) patients in the EGFR group with lymph nodes >1.5cm, and reader 2 identified 18 (19%) (kappa 0.969). Patients with ALK rearrangements were more likely to have multifocal lymphadenopathy. Reader 1 identified 22 (73%) ALK patients versus 35 (36%) EGFR patients with multifocal thoracic nodal enlargement, while reader 2 identified 20 (67%) ALK patients versus 30 (31%) EGFR patients (kappa 0.953). 92% of ALK positive lesions were solid.
conclusionALK positive lung adenocarcinomas are more likely than EGFR mutant lung adenocarcinomas to be associated with larger volume, multifocal thoracic lymphadenopathy. While routine testing for ALK should be standard, the presence of such characteristics in a solid tumor should further prompt testing for ALK rearrangement.
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