ArticleInfection and immunity2015
Macrophages are the determinant of resistance to and outcome of nonlethal Babesia microti infection in mice.
Article in Infection and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
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- Disruption of the CD47-SIRPα Axis Causes Profound Reduction of Parasitaemia in Mice Infected With Babesia microti.Parasite immunology · 2026Article
- Immunity beyond borders: non-lethalFrontiers in immunology · 2026Article
- Activation of macrophages by extracellular vesicles derived fromInfection and immunity · 2025Article
- Investigation of Comorbidity and Risk Factors Analysis During Lumpy Skin Disease Outbreaks in India.Microorganisms · 2025Article
- Tumor Necrosis Factor Receptors and C-C Chemokine Receptor-2 Positive Cells Play an Important Role in the Intraerythrocytic Death and Clearance ofPathogens (Basel, Switzerland) · 2024Article
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- Trust the Process: Prolonged Babesia Parasitemia in an Elderly Man with Asplenia from the American Midwest.The American journal of case reports · 2022Article
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- The Cross-Species Immunity During AcuteFrontiers in cellular and infection microbiology · 2022Article
- Human Babesiosis in Europe.Pathogens (Basel, Switzerland) · 2021Review
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- Congenital Transmission of Apicomplexan Parasites: A Review.Frontiers in microbiology · 2021Review
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- Protozoan ParasiteFrontiers in microbiology · 2019Article
- Robust adaptive immune response againstBlood advances · 2018Article
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- Age-Related Differential Stimulation of Immune Response byFrontiers in immunology · 2018Article
- Elimination ofJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Evaluation of a Major Surface Antigen ofFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, we examined the contributions of macrophages to the outcome of infection with Babesia microti, the etiological agent of human and rodent babesiosis, in BALB/c mice. Mice were treated with clodronate liposome at different times during the course of B. microti infection in order to deplete the macrophages. Notably, a depletion of host macrophages at the early and acute phases of infection caused a significant elevation of parasitemia associated with remarkable mortality in the mice. The depletion of macrophages at the resolving and latent phases of infection resulted in an immediate and temporal exacerbation of parasitemia coupled with mortality in mice. Reconstituting clodronate liposome-treated mice at the acute phase of infection with macrophages from naive mice resulted in a slight reduction in parasitemia with improved survival compared to that of mice that received the drug alone. These results indicate that macrophages play a crucial role in the control of and resistance to B. microti infection in mice. Moreover, analyses of host immune responses revealed that macrophage-depleted mice diminished their production of Th1 cell cytokines, including gamma interferon (IFN-γ) and tumor necrosis factor alpha (TNF-α). Furthermore, depletion of macrophages at different times exaggerated the pathogenesis of the infection in deficient IFN-γ(-/-) and severe combined immunodeficiency (SCID) mice. Collectively, our data provide important clues about the role of macrophages in the resistance and control of B. microti and imply that the severity of the infection in immunocompromised patients might be due to impairment of macrophage function.
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