ArticleInfection and immunity2015
Leishmania major telomerase TERT protein has a nuclear/mitochondrial eclipsed distribution that is affected by oxidative stress.
Article in Infection and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Molecular and Structural Characterization of an Immunopurified Telomerase fromMicroorganisms · 2025Article
- Cell Cycle, Telomeres, and Telomerase inCells · 2021Review
- Diverse telomeres in trypanosomatids.Parasitology · 2021Article
- Biophysical and Biochemical Comparison of Extracellular Vesicles Produced by Infective and Non-Infective Stages ofInternational journal of molecular sciences · 2021Article
- Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing.International journal of molecular sciences · 2019Review
- Characterization and functionality of two members of the SPFH protein superfamily, prohibitin 1 and 2 in Leishmania major.Parasites & vectors · 2018Article
- Promoter mutations and cellular distribution of telomerase in non-clear cell and clear cell hepatocellular carcinoma.Oncotarget · 2017Article
- Self-adjuvanting C18 lipid vinil sulfone-PP2A vaccine: study of the induced immunomodulation againstOpen biology · 2017Article
- Telomere biology: Rationale for diagnostics and therapeutics in cancer.RNA biology · 2015Review
- Exosomes Derived from Breast Cancer Cells, Small Trojan Horses?Journal of mammary gland biology and neoplasia · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In its canonical role the reverse transcriptase telomerase recovers the telomeric repeats that are lost during DNA replication. Other locations and activities have been recently described for the telomerase protein subunit TERT in mammalian cells. In the present work, using biochemistry, molecular biology, and electron microscopy techniques, we found that in the human parasite Leishmania major, TERT (and telomerase activity) shared locations between the nuclear, mitochondrial, and cytoplasmic compartments. Also, some telomerase activity and TERT protein could be found in ∼ 100-nm nanovesicles. In the mitochondrial compartment, TERT appears to be mainly associated with the kinetoplast DNA. When Leishmania cells were exposed to H2O2, TERT changed its relative abundance and activity between the nuclear and mitochondrial compartments, with the majority of activity residing in the mitochondrion. Finally, overexpression of TERT in Leishmania transfected cells not only increased the parasitic cell growth rate but also increased their resistance to oxidative stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.