ReviewBrain research2015
Out with the old and in with the new: Synaptic mechanisms of extinction in the amygdala.
Review in Brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04468360 (Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD- Pharmacokinetic Studies), which is not on this map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD- Pharmacokinetic Studies
Who cites it
28 citing papers in PubMed.
- Heterogeneous plasticity of amygdala interneurons in associative learning and extinction.Nature communications · 2025Article
- Neuroactive steroids and the pathophysiology of PTSD: Biomarkers for treatment targeting.Neuroscience and biobehavioral reviews · 2025Review
- Spurious autobiographical memories of psychosis: a dopamine-gated neuroplasticity account for relapse and treatment-resistant psychosis.Psychological medicine · 2025Review
- Abnormal response to chronic social defeat stress and fear extinction in a mouse model ofFrontiers in neuroscience · 2025Article
- A biopsychosocial model of MDMA-assisted therapy in application: Dyadic One Session Treatment for specific phobia.Frontiers in psychiatry · 2025Article
- The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity.Molecular psychiatry · 2024Article
- The interaction of Synapsin 2a and Synaptogyrin-3 regulates fear extinction in mice.The Journal of clinical investigation · 2024Article
- Enhancing Fear Extinction: Pharmacological Approaches.Current topics in behavioral neurosciences · 2023Article
- Targeting neuronal nitric oxide synthase and the nitrergic system in post-traumatic stress disorder.Psychopharmacology · 2022Review
- Hippocampus and amygdala fear memory engrams re-emerge after contextual fear relapse.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Pleiotropic endophenotypic and phenotype effects of GABAergic neurosteroid synthesis deficiency in posttraumatic stress disorder.Current opinion in endocrine and metabolic research · 2022Article
- Persistent up-regulation of polyribosomes at synapses during long-term memory, reconsolidation, and extinction of associative memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Pharmacological sequestration of mitochondrial calcium uptake protects against dementia and β-amyloid neurotoxicity.Scientific reports · 2022Article
- A role for deficits in GABAergic neurosteroids and their metabolites with NMDA receptor antagonist activity in the pathophysiology of posttraumatic stress disorder.Journal of neuroendocrinology · 2022Review
- A proposed mechanism for the MDMA-mediated extinction of traumatic memories in PTSD patients treated with MDMA-assisted therapy.Frontiers in psychiatry · 2022Review
- Associations between PTSD-Related extinction retention deficits in women and plasma steroids that modulate brain GABANeurobiology of stress · 2020Article
- Maturational Changes in Prefrontal and Amygdala Circuits in Adolescence: Implications for Understanding Fear Inhibition during a Vulnerable Period of Development.Brain sciences · 2019Review
- Phosphoproteomic analysis of cocaine memory extinction and reconsolidation in the nucleus accumbens.Psychopharmacology · 2019Article
- Developmental Aspects of Glucose and Calcium Availability on the Persistence of Memory Function Over the Lifespan.Frontiers in aging neuroscience · 2019Review
- Emotional Theory of Rationality.Frontiers in integrative neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Considerable research indicates that long-term synaptic plasticity in the amygdala underlies the acquisition of emotional memories, including those learned during Pavlovian fear conditioning. Much less is known about the synaptic mechanisms involved in other forms of associative learning, including extinction, that update fear memories. Extinction learning might reverse conditioning-related changes (e.g., depotentiation) or induce plasticity at inhibitory synapses (e.g., long-term potentiation) to suppress conditioned fear responses. Either mechanism must account for fear recovery phenomena after extinction, as well as savings of extinction after fear recovery. This article is part of a Special Issue entitled SI: Brain and Memory.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.