Evidence map›Paper›PMID 25312829›Full record

ArticleBrain research2015

Baseline effects of transcranial direct current stimulation on glutamatergic neurotransmission and large-scale network connectivity.

Michael A Hunter, Brian A Coffman, Charles Gasparovic, Vince D Calhoun, Michael C Trumbo, Vincent P Clark

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07196423 (Glutamate Changes as a New Neurocognitive Marker in Psychosis), which is not on this map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07196423 narecruitingnot on this mapstarted 2026, after this paper: background citation

Glutamate Changes as a New Neurocognitive Marker in Psychosis

TypeinterventionalSponsorUniversity of NottinghamRan2026 to 2027Enrolled106ConditionsFirst Episode Psychosis (FEP), PsychosisArmsTranscranial direct current stimulation (tDCS), Magnetic Resonance Imaging
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 133 citations in OpenAlex.

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  12. Neuroimaging Biomarkers in Addiction.medRxiv : the preprint server for health sciences · 2024
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  17. Dopamine Alters the Effect of Brain Stimulation on Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Michael A HunterPsychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, USA; Department of Psychology, The University of New Mexico, NM, USA; The Mind Research Network, Albuquerque, NM, USA; Department of Psychiatry, The University of New Mexico School of Medicine, Albuquerque, NM, USA.
Brian A CoffmanPsychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, USA; Department of Psychology, The University of New Mexico, NM, USA; The Mind Research Network, Albuquerque, NM, USA.
Charles GasparovicThe Mind Research Network, Albuquerque, NM, USA.
Vince D CalhounThe Mind Research Network, Albuquerque, NM, USA; Department of Psychiatry, The University of New Mexico School of Medicine, Albuquerque, NM, USA; Department of Neurosciences, The University of New Mexico, Albuquerque, NM, USA; Department of Electrical and Computer Engineering, The University of New Mexico, Albuquerque, NM, USA.
Michael C TrumboPsychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, USA; Department of Psychology, The University of New Mexico, NM, USA; The Mind Research Network, Albuquerque, NM, USA.
Vincent P ClarkPsychology Clinical Neuroscience Center, The University of New Mexico, Albuquerque, NM, USA; Department of Psychology, The University of New Mexico, NM, USA; The Mind Research Network, Albuquerque, NM, USA; Department of Neurosciences, The University of New Mexico, Albuquerque, NM, USA. Electronic address: vclark@unm.edu.
University of New Mexico · USMind Research Network · US

Funding

Transcranial Direct Current Stimulation for Treatment of Auditory Verbal HalluciP20GM103472 · NIGMS · THE MIND RESEARCH NETWORK · PI ABBOTT, CHRISTOPHER C · 2012 to 2017
$14.3M
Multivariate methods for identifying multitask/multimodal brain imaging biomarkersR01EB006841 · NIBIB · THE MIND RESEARCH NETWORK · PI VINCE D CALHOUN, Sergey Plis · 2007 to 2026
$9.8M
Informed Data-Driven Fusion of Behavior, Brain Function, and GenesR01EB005846 · NIBIB · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D · 2005 to 2016
$5.5M
Unified multivariate data-driven solutions for static and dynamic brain connectivityR01EB020407 · NIBIB · THE MIND RESEARCH NETWORK · PI ADALI, TULAY, CALHOUN, VINCE D · 2015 to 2018
$2.7M
CRCNS: Bayesian Analysis of Neural-Behavioral Interactions in Mental IllnessR01MH076282 · NIMH · UNIVERSITY OF NEW MEXICO · PI LANE, TERRAN D. R. · 2005 to 2007
$964k
Fast Network Inference Methods for Connectome AnalysisR21MH097201 · NIMH · UNIVERSITY OF NEW MEXICO · PI LANE, TERRAN D. R. · 2012 to 2013
$389k
NIBIB NIH HHS R01 EB005846NIBIB NIH HHS R01EB005846NIBIB NIH HHS R01 EB006841NIBIB NIH HHS R01EB006841NIBIB NIH HHS R01 EB020407NIGMS NIH HHS P20 GM103472NIGMS NIH HHS P20GM103472NIMH NIH HHS R01 MH076282NIMH NIH HHS R21 MH097201NIMH NIH HHS R21MH097201
6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) modulates glutamatergic neurotransmission and can be utilized as a novel treatment intervention for a multitude of populations. However, the exact mechanism by which tDCS modulates the brain׳s neural architecture, from the micro to macro scales, have yet to be investigated. Using a within-subjects design, resting-state functional magnetic resonance imaging (rs-fMRI) and proton magnetic resonance spectroscopy ((1)H MRS) were performed immediately before and after the administration of anodal tDCS over right parietal cortex. Group independent component analysis (ICA) was used to decompose fMRI scans into 75 brain networks, from which 12 resting-state networks were identified that had significant voxel-wise functional connectivity to anatomical regions of interest. (1)H MRS was used to obtain estimates of combined glutamate and glutamine (Glx) concentrations from bilateral intraparietal sulcus. Paired sample t-tests showed significantly increased Glx under the anodal electrode, but not in homologous regions of the contralateral hemisphere. Increases of within-network connectivity were observed within the superior parietal, inferior parietal, left frontal-parietal, salience and cerebellar intrinsic networks, and decreases in connectivity were observed in the anterior cingulate and the basal ganglia (p<0.05, FDR-corrected). Individual differences in Glx concentrations predicted network connectivity in most of these networks. The observed relationships between glutamatergic neurotransmission and network connectivity may be used to guide future tDCS protocols that aim to target and alter neuroplastic mechanisms in healthy individuals as well as those with psychiatric and neurologic disorders.

Indexed as

Transcranial Direct Current StimulationBrainBrain MappingFemaleGlutamic AcidGlutamineHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleNerve NetSynaptic TransmissionYoung AdultGlutamic AcidGlutamineFunctional network connectivity (FNC)Glutamine–glutamate (Glx)Independent component analysis (ICA)Magnetic resonance spectroscopy (MRS)Parietal lobeResting-state functional magnetic resonance imaging (rs-fMRI)Transcranial direct current stimulation (tDCS)

Identifiers

PMID25312829
PMCPMC4358793
OpenAlexW2060112068

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.