ArticleExperimental animals2015
Ovariectomy differential influence on some hemostatic markers of mice and rats.
Article in Experimental animals, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Impact of Female Reproductive Hormones on Surgically Induced Hemorrhage: A Translational Animal Model.Journal of clinical medicine · 2026Article
- GPER1 activation regulates renal purinergic P2YAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Sex-specific lymphatic responses to estrogen shape atherosclerosis in high-risk mice.Frontiers in cardiovascular medicine · 2026Article
- Characterization of aortic endothelial dysfunction in ovariectomized allergic asthmatic mice.PloS one · 2026Article
- Myocardial transcriptomic and proteomic landscapes across the menopausal continuum in a murine model of chemically induced accelerated ovarian failure.Physiological genomics · 2025Article
- Sex dimorphism controls dysbindin-related cognitive dysfunctions in mice and humans with the contribution of COMT.Molecular psychiatry · 2024Article
- Heat-killed Limosilactobacillus reuteri ATCC PTA 6475 prevents bone loss in ovariectomized mice: A preliminary study.PloS one · 2024Article
- Estradiol improves behavior in FAD transgenic mice that expressFrontiers in endocrinology · 2024Article
- Attenuative effects of collagen peptide from milkfish (Food science & nutrition · 2024Article
- Investigation of murine host sex as a biological variable in epithelial barrier function and muscle contractility in human intestinal organoids.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Granular PEG hydrogels mediate osteoporotic MSC clustering via N-cadherin influencing the pro-resorptive bias of their secretory profile.Acta biomaterialia · 2022Article
- Estrous cycle and ovariectomy-induced changes in visceral pain are microbiota-dependent.iScience · 2021Article
- Unexpected Role of Physiological Estrogen in Acute Stress-Induced Memory Deficits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Maca extracts and estrogen replacement therapy in ovariectomized rats exposed at high altitude.Reproductive medicine and biology · 2021Article
- Ovariectomized rat model of osteoporosis: a practical guide.EXCLI journal · 2020Review
- Nonclinical aspects of venous thrombosis in pregnancy.Birth defects research. Part C, Embryo today : reviews · 2015Review
- Applicability of Global Hemostatic Tools for Evaluation of Hemostatic State and Detection of Thrombosis in Cats With Cardiomyopathies.Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rodent ovariectomy is an experimental method to eliminate the main source of sexual steroids. This work explored for the first time the ovariectomy temporal changes induced in the hemostatic coagulation markers: prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), and fibrinogen concentration (FIB) along with uterine weight on adult female CD1 mice and Wistar rats. Uterine weight (Uw) was assessed before ovariectomy (control), and 1, 3, 5, 7, 9, 16, and 21 days after surgery. PT, aPTT, TT and FIB were estimated the same days, using reported standard techniques. Ovariectomy decreased Uw, since day 1; and from day 10 to 21 reached the lowest values for both species. After day 1, mice hemostatic parameters changed (PT +10%, P<0.05; aPTT +53%, P<0.05; TT -24%, P<0.05; FIB +67%, P<0.05). Rats showed significant changes only in TT and FIB (TT -13%, P<0.001; FIB +65%, P<0.001). Neither mice PT, aPTT and TT, recovered control values after 21 days. In the rats from day 5 to 16 aPTT diminished (18-23%, P<0.05) recovering to control values on day 21, TT after 9 days and PT on day 16. In both species, FIB returned to its control values after 9 days. Ovariectomy differentially altered the PT hemostatic parameter of mice and rats indicating a non-equivalence among both species behaviour for experimental studies of blood coagulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.