ArticleJournal of medical genetics1989
Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene.
Article in Journal of medical genetics, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 77 citations in OpenAlex.
- Telomere shortening and Alzheimer's disease.Neuromolecular medicine · 2013Review
- Linkage disequilibrium interval mapping of quantitative trait loci.BMC genomics · 2006Article
- A coalescent model of ancestry for a rare allele.Genetics · 2000Article
- Disequilibrium likelihoods for fine-scale mapping of a rare allele.American journal of human genetics · 1998Article
- An ancestral core haplotype defines the critical region harbouring the North Carolina macular dystrophy gene (MCDR1).Journal of medical genetics · 1997Article
- Fine-scale genetic mapping based on linkage disequilibrium: theory and applications.American journal of human genetics · 1997Article
- Likelihood methods for locating disease genes in nonequilibrium populations.American journal of human genetics · 1995Article
- Linkage disequilibrium in the region of the autosomal dominant polycystic kidney disease gene (PKD1).American journal of human genetics · 1994Article
- Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region.American journal of human genetics · 1994Article
- Allele frequencies and linkage disequilibrium of polymorphic DNA markers of the Huntington disease region in the German population.Human genetics · 1993Article
- Significant linkage disequilibrium between the Huntington's disease locus and markers at loci D4S10, D4S95, and D4S111 in Northern Ireland.Journal of medical genetics · 1993Article
- Linkage disequilibrium in the neurofibromatosis 1 (NF1) region: implications for gene mapping.American journal of human genetics · 1993Article
- Article
- Age at onset in Huntington's disease and methylation at D4S95.Journal of medical genetics · 1993Article
- Significant linkage disequilibrium between the Huntington disease gene and the loci D4S10 and D4S95 in the Dutch population.American journal of human genetics · 1992Article
- Expected behavior of conditional linkage disequilibrium.American journal of human genetics · 1992Article
- A recombination event that redefines the Huntington disease region.American journal of human genetics · 1992Article
- Genetic and physical mapping on chromosome 4 narrows the localization of the gene for facioscapulohumeral muscular dystrophy (FSHD).American journal of human genetics · 1992Article
- The epidemiology of Huntington's disease.Human genetics · 1992Review
- Recombination of 4p16 DNA markers in an unusual family with Huntington disease.American journal of human genetics · 1992Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Analysis of many families with linked DNA markers has provided support for the Huntington's disease (HD) gene being close to the telomere on the short arm of chromosome 4. However, analysis of recombination events in particular families has provided conflicting results about the precise location of the HD gene relative to these closely linked DNA markers. Here we report an investigation of linkage disequilibrium between six DNA markers and the HD gene in 75 separate families of varied ancestry. We show significant non-random association between alleles detected at D4S95 and D4S98 and the mutant gene. These data suggest that it may be possible to construct high and low risk haplotypes, which may be helpful in DNA analysis and genetic counselling for HD, and represent independent evidence that the gene for HD is centromeric to more distally located DNA markers such as D4S90. This information may be helpful in defining a strategy to clone the gene for HD based on its location in the human genome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.