Evidence map›Paper›PMID 25311922›Full record

ReviewAdvances in genetics2014

Methods for gene transfer to the central nervous system.

Boris Kantor, Rachel M Bailey, Keon Wimberly, Sahana N Kalburgi, Steven J Gray

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed.

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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Boris KantorDepartment of Pharmacology, Physiology, and Neuroscience, University of South Carolina, Columbia, SC, USA.
Rachel M BaileyGene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Keon WimberlyGene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sahana N KalburgiGene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Steven J GrayGene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

UNC Neuroscience Center Research Cores: MicroscopyP30NS045892 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2003 to 2022
$11.5M
Giant Axonal Neuropathy Gene TherapyR01NS087175 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI ARMAO, DIANE, GRAY, STEVEN J · 2014 to 2018
$1.7M
NINDS NIH HHS P30 NS045892NINDS NIH HHS R01 NS087175
6 · The paper itself

Abstract

Gene transfer is an increasingly utilized approach for research and clinical applications involving the central nervous system (CNS). Vectors for gene transfer can be as simple as an unmodified plasmid, but more commonly involve complex modifications to viruses to make them suitable gene delivery vehicles. This chapter will explain how tools for CNS gene transfer have been derived from naturally occurring viruses. The current capabilities of plasmid, retroviral, adeno-associated virus, adenovirus, and herpes simplex virus vectors for CNS gene delivery will be described. These include both focal and global CNS gene transfer strategies, with short- or long-term gene expression. As is described in this chapter, an important aspect of any vector is the cis-acting regulatory elements incorporated into the vector genome that control when, where, and how the transgene is expressed.

Indexed as

Central Nervous SystemGenetic TherapyGene Transfer TechniquesAdenoviridaeGene ExpressionGenetic VectorsHumansLentivirusSimplexvirusAAVAdenovirusCNSGene therapyLentivirusPlasmidPromoterVector

Identifiers

PMID25311922
PMCPMC4519829

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.