ArticleJournal of veterinary internal medicine
Effect of duration of packed red blood cell storage on morbidity and mortality in dogs after transfusion: 3,095 cases (2001-2010).
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Stability of packed cell volume in dogs with nonregenerative anaemias from immediate to 24 hours posttransfusion.Australian veterinary journal · 2026Article
- Evaluation of post-transfusion RBC alloimmunization in dogs using a gel-column crossmatch with and without anti-canine globulin enhancement.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Evaluation of leukocyte depletion of packed red blood cell units and impact on clinically observed transfusion reactions.Frontiers in veterinary science · 2023Article
- Evaluation of selected hematological, biochemical and oxidative stress parameters in stored canine CPDA-1 whole blood.BMC veterinary research · 2022Article
- Randomized double-blinded clinical trial on acute transfusion reactions in dogs receiving leukoreduced versus nonleukoreduced packed red blood cells.Journal of veterinary internal medicine · 2021Article
- Effect of Leukoreduction on Hematobiochemical Parameters and Storage Hemolysis in Canine Whole Blood Units.Animals : an open access journal from MDPI · 2021Article
- Outcomes and Blood Product Use in 89 Surgically Managed and 79 Medically Managed Cases of Acute Spontaneous Hemoperitoneum in the Dog.Frontiers in veterinary science · 2021Article
- Neutrophil extracellular traps in stored canine red blood cell units.Journal of veterinary internal medicine · 2020Article
- ACVIM consensus statement on the treatment of immune-mediated hemolytic anemia in dogs.Journal of veterinary internal medicine · 2019Article
- Effects of irradiation and leukoreduction on down-regulation of CXCL-8 and storage lesion in stored canine whole blood.Journal of veterinary science · 2019Article
- Mechanisms of Hemolysis During Sepsis.Inflammation · 2018Review
- Effects of Leukoreduction and Storage on Erythrocyte Phosphatidylserine Expression and Eicosanoid Concentrations in Units of Canine Packed Red Blood Cells.Journal of veterinary internal medicine · 2017Article
- Stored Canine Whole Blood Units: What is the Real Risk of Bacterial Contamination?Journal of veterinary internal medicine · 2016Article
- Development and Evaluation of a PCV-Dependent Visual Hemolysis Color Scale for Packed Red Blood Cell Products.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Article
- A prospective multicenter observational study assessing incidence and risk factors for acute blood transfusion reactions in dogs.Journal of veterinary internal medicineArticle
- Effects of Coincubation With Crystalloids or Medications on Canine Packed Red Blood Cells: An In Vitro Evaluation.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccumulating evidence suggests that transfusion of packed red blood cells (PRBCs) stored for >14 days is associated with increased rates of sepsis, multiple organ dysfunction, and mortality in human patients.
objectiveTo determine if duration of PRBC storage has an effect on morbidity and mortality in dogs after transfusion. ANIMALS: Dogs admitted to the Matthew J Ryan Veterinary Hospital of the University of Pennsylvania.
methodsA retrospective case review of dogs identified through blood bank logbooks that received PRBC transfusions (minimum, 5 mL/kg) between 2001 and 2010. Dogs were categorized according to major cause of anemia (eg, hemorrhage, hemolysis, ineffective erythropoiesis) for analysis.
resultsA total of 3,095 dogs received 5,412 PRBC units. Longer duration of PRBC storage was associated with development of new or progressive coagulation failure (P = .001) and thromboembolic disease (P = .005). There was no association between duration of PRBC storage and survival for all dogs overall. However, a logistic regression model indicated that for dogs with hemolysis, 90% of which had immune-mediated hemolytic anemia, longer duration of PRBC storage was a negative risk factor for survival. For every 7 day increase in storage, there was a 0.79 lesser odds of 30 day survival (95% CI, 0.64-0.97; P = .024). CONCLUSIONS AND CLINICAL IMPORTANCE: Duration of PRBC storage does not appear to be a major contributing factor to mortality in the overall canine population. However, longer duration of PRBC storage may negatively impact outcome in dogs with immune-mediated hemolytic anemia, thus warranting further investigation with prospective studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.