ArticleSchizophrenia research2014
Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia.
Article in Schizophrenia research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mood Disorders and Gluten: It's Not All in Your Mind! A Systematic Review with Meta-Analysis.Nutrients · 2018Pooled it
- Randomized double-blind inpatient study of a gluten-free diet for negative symptoms in people with schizophrenia.Schizophrenia research · 2026Trial
- Randomized controlled trial of a gluten-free diet in patients with schizophrenia positive for antigliadin antibodies (AGA IgG): a pilot feasibility studyJournal of psychiatry & neuroscience : JPN · 2019Trial
- The Effects of a Gluten-Free Diet on Immune Markers and Kynurenic Acid Pathway Metabolites in Patients With Schizophrenia Positive for Antigliadin Antibodies Immunoglobulin G.Journal of clinical psychopharmacologyTrial
- Psychiatric Symptoms Associated with Non-Celiac Gluten Sensitivity: A Focused Narrative Review.Nutrients · 2026Review
- T cells are associated with negative symptoms in persons with anti-gliadin antibody positive schizophrenia and related disorders.Schizophrenia research · 2025Article
- Autoantibodies and Inflammation in Schizophrenia.Psychiatry and clinical neurosciences · 2025Review
- Measuring oxidative stress by the iridium reducing capacity assay (Ir-RCA).Advances in redox research · 2025Article
- Sex differences in abnormal gluten response and predictors of gluten sensitivity in patients with schizophrenia.Frontiers in immunology · 2025Article
- Immunologic profiling in schizophrenia and rheumatoid arthritis.Psychiatry research · 2022Article
- Non-Celiac Gluten Sensitivity in the Context of Functional Gastrointestinal Disorders.Nutrients · 2020Review
- Sex Differences in the Gut-Brain Axis: Implications for Mental Health.Current psychiatry reports · 2020Review
- Inflammation in Mental Disorders: Is the Microbiota the Missing Link?Neuroscience bulletin · 2020Review
- Gut permeability and mimicry of the Glutamate Ionotropic Receptor NMDA type Subunit Associated with protein 1 (GRINA) as potential mechanisms related to a subgroup of people with schizophrenia with elevated antigliadin antibodies (AGA IgG).Schizophrenia research · 2019Article
- Gliadin-related antibodies in schizophrenia.Schizophrenia research · 2018Article
- Anti gliadin antibodies (AGA IgG) related to peripheral inflammation in schizophrenia.Brain, behavior, and immunity · 2018Article
- Differential antibody responses to gliadin-derived indigestible peptides in patients with schizophrenia.Translational psychiatry · 2017Article
- Modified Mediterranean Diet for Enrichment of Short Chain Fatty Acids: Potential Adjunctive Therapeutic to Target Immune and Metabolic Dysfunction in Schizophrenia?Frontiers in neuroscience · 2017Article
- Properties of Gluten Intolerance: Gluten Structure, Evolution, Pathogenicity and Detoxification Capabilities.Nutrients · 2016Review
- Kynurenine and Tryptophan Levels in Patients With Schizophrenia and Elevated Antigliadin Immunoglobulin G Antibodies.Psychosomatic medicine · 2016Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The relationship between gluten sensitivity and schizophrenia has been of increasing interest and novel mechanisms explaining this relationship continue to be described. Our study in 100 people with schizophrenia compared to 100 matched controls replicates a higher prevalence of gluten sensitivity and higher mean antigliadin IgG antibody levels schizophrenia (2.9 ± 7.7 vs. 1.3 ± 1.3, p = 0.046, controlled for age). Additionally, we examined symptoms within the schizophrenia group and found that while positive symptoms are significantly lower in people who have elevated antigliadin antibodies (AGA; 4.11 ± 1.36 vs. 6.39 ± 2.99, p = 0.020), no robust clinical profile differentiates between positive and negative antibody groups. Thus, identifying people in schizophrenia who may benefit from a gluten-free diet remains possible by blood test only.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.